580 Result(s)
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Chapter
Compartmentalization within the Common Mucosal Immune System
The mucosal tissues and external secretory glands of humans and animals reveal a remarkable preponderance of IgA-producing plasma cells1 which, as demonstrated in animal experiments, are derived from precursors i...
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γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity
Mice rendered deficient in αβ T-cells by single-gene knockout mutation show enhanced levels of autoantibody formation and even some symptoms of autoimmune disease. This is remarkable given that most experiment...
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Glucocorticoids and TGF-β1 Synergize in Augmenting Fibroblast Mediated Contraction of Collagen Gels
TGF-β plays a central role in the initiation and progression of pulmonary fibrosis. Glucocorticoids are frequently used to treat fibrotic diseases, but beneficial effects are often modest. Both TGF-β and gluco...
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Glucocorticoids Modulate TGF-β Production
TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-β isoforms a...
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Glucocorticoids Modulate TGF-β Production by Human Fetal Lung Fibroblasts
TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGF-β isoforms a...
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IL-4 and IL-13 Induce Chemotaxis of Human Foreskin Fibroblasts, But Not Human Fetal Lung Fibroblasts
Through shared receptors, IL-4 and IL-13 have been suggested to regulate not only inflammatory cells, but also to play a role in stimulating fibroblasts during fibrotic processes. Previous studies have shown t...
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Polyclonal B-Cell Expansion in the Cerebrospinal Fluid of Patients with Psedotumor Cerebri
To investigate the hypothesis that pseudotumor cerebri (PTC) is associated with humoral immunity, we analyzed immunoglobulin heavy chain variable region (Ig-V H ) genes of B cell...
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Using support vector classification for SAR of fentanyl derivatives
To discriminate between fentanyl derivatives with high and low activities.
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Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats
To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats.
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Akhil Kakroo
Recent advances in immunologic techniques have lead to increased recognition of primary immunodeficiencies. A review of patients with suspected immunodeficiencies in a Taiwan tertiary hospital from January 198...
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Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B
To examine the effects of Astragalus polysaccharide (APS), a component of an aqueous extract of Astragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor ...
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Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells
To determine the inhibitory effect of the synthetic STAT3 siRNA on the expression of STAT3 gene in human laryngeal cancer cell lines Hep2 and to investigate the effect of STAT3 siRNA on growth and apoptosis in...
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The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis
To study the anti-endotoxic effect of o-aminobenzoic acid (OABA) isolated from Banlangen(BLG).
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Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population
To determine the frequencies of polymorphism and haplotype in the transforming growth factor-beta 1 (TGF-β1) gene promoter in the Chinese population and to investigate the susceptibility of this population to ...
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Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis
To explore the relationship between differential leucocyte count and coronary atherosclerosis.
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Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes
To study effects of arachidonic acid (AA) and its metabolites on the hyposmotic membrane stretch-induced increase in calcium-activated potassium currents (IKCa) in gastric myocytes.
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Article
Radioimmunotherapy of carcinoma of colon with [131I]- labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen
To study the distribution of [131I]-labeled anti-CEA MoAbs and its therapeutic effect on the human colonic cancer model in nude mice.
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Article
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
To study the immunosuppressive activity of SM735 {[3 -(12-β-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal anti-inflammatory drug structure, with the aim of find...
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Article
C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats
Advanced glycation endproducts (AGE) have been implicated in the pathogenesis of diabetic complications, including diabetic cardiovascular dysfunction. 3-[2-(4-Bromo-phenyl)-1-methyl-2-oxo-ethyl]-4,5,6,7-tetra...
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Preparation and development of equine hyperimmune globulin F(ab′)2 against severe acute respiratory syndrome coronavirus
The resurgence of severe acute respiratory syndrome (SARS) is still a threat because the causative agent remaining in animal reservoirs is not fully understood, and sporadic cases continue to be reported. Deve...
