53 Result(s)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

Targeting tumor suppressor p53 for organ fibrosis therapy

Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its ...

Yi-Ni Bao, Qiao Yang, **n-Lei Shen, Wen-Kai Yu, Li Zhou… in Cell Death & Disease (2024)

Article

A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer

Breast cancer (BC) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. The 5-year survival rate is over 90% in BC patients, but once BC cells metastasis into distal org...

Wen-Der Lin, Chia-Hao Chang, Jhih-Kai Pan, Forn-Chia Lin… in Cell Death & Disease (2024)

Article

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung a...

Jie Wu, Ting Wen, Antonio Marzio, Dingli Song, Sisi Chen… in Cell Death & Disease (2024)

Article

A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens

The plasma membrane is enriched for receptors and signaling proteins that are accessible from the extracellular space for pharmacological intervention. Here we conducted a series of CRISPR screens using human ...

Nicole M. Mattson, Anthony K. N. Chan… in Nature Structural & Molecular Biology (2024)

Article

Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution

Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow microenvironment to expand and re...

Seyram Yao Adzraku, Can Cao, Qi Zhou, Ke Yuan, **aowen Hao, Yue Li… in Cell Death & Disease (2024)

Article

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...

Yuan-li Ai, Wei-jia Wang, Fan-jian Liu, Wei Fang, Hang-zi Chen… in Cell Research (2023)

Article

CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease

Calcific aortic valve disease (CAVD) is a common valve disease with an increasing incidence, but no effective drugs as of yet. With the development of sequencing technology, non-coding RNAs have been found to ...

Yuqi Zheng, Shuyu Wen, Shijiu Jiang, Shaolin He, Weihua Qiao, Yi Liu… in BMC Genomics (2023)

Article

A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Bone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in lung cancer patients. However, the regulatory mechanisms under...

Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang… in Cell Death & Disease (2023)

Article

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this ca...

Tian-yue Liu, Chen-chen Hu, Chen-ying Han, Si-yi Mao, Wen-xin Zhang… in Biology Direct (2023)

Article

A heterophil/lymphocyte-selected population reveals the phosphatase PTPRJ is associated with immune defense in chickens

Quantification of leukocyte profiles is among the simplest measures of animal immune function. However, the relationship between H/L ratio and innate immunity and the measure’s utility as an index for heteroph...

Jie Wang, ** Zhang, Qiao Wang, Qi Zhang, Mamadou Thiam, Bo Zhu… in Communications Biology (2023)

Article

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) i...

Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen… in Nature Metabolism (2022)

Article

Transcriptome analysis of sweet potato responses to potassium deficiency

As one of three essential nutrients, potassium is regarded as a main limiting factor for growth and development in plant. Sweet potato (Ipomoea batatas L.) is one of seven major food crops grown worldwide, and is...

Fang Wang, Wen-Fang Tan, Wei Song, Song-Tao Yang, Shuai Qiao in BMC Genomics (2022)

Article

An orally available M^pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Emerging SARS-CoV-2 variants continue to cause waves of new infections globally. Develo** effective antivirals against SARS-CoV-2 and its variants is an urgent task. The main protease (M^pro) of SARS-CoV-2 is an...

Bao-Xue Quan, Hui** Shuai, An-Jie **a, Yuxin Hou, Rui Zeng… in Nature Microbiology (2022)

Article

Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by p...

Kan **ng Wu, Natalie Jia Ying Yeo, Chun Yi Ng, Florence Wen **g Chioh… in BMC Biology (2022)

Article

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway

Although there are many studies on the relationship between genetic polymorphisms and the incidence of diseases, mechanisms are rarely known. We report the mechanism by which signal transducer and activator of...

Caie Wang, Na Gao, Lukui Yang, Yuanyuan Guo, Yan Fang, Tong Wang… in Cell Death & Disease (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)