10 Result(s)
within
Wen**g Zhuang
Cancer Research
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Article
Interleukin-10 −1082 promoter polymorphism and gastric cancer risk in a Chinese Han population
Studies investigating the association between interleukin-10 (IL-10) −1082 promoter polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the IL-10 −1082 promo...
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Article
Open AccessTumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma
DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance...
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Article
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3
Peizeng Yang, Zhenglin Yang and colleagues report results of a genome-wide association study of Vogt-Koyanagi-Harada syndrome. They confirm strong association with the HLA region and identify two new susceptibili...
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Article
Open AccessPredicting multi-level drug response with gene expression profile in multiple myeloma using hierarchical ordinal regression
Multiple myeloma (MM), like other cancers, is caused by the accumulation of genetic abnormalities. Heterogeneity exists in the patients’ response to treatments, for example, bortezomib. This urges efforts to i...
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Article
Open AccessTFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas
Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Patients are dia...
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Article
Downregulation of ITGA6 confers to the invasion of multiple myeloma and promotes progression to plasma cell leukaemia
Secondary plasma cell leukaemia (sPCL) is an aggressive form of multiple myeloma (MM), but the mechanism underlying MM progresses into PCL remains unknown.
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Article
Open AccessLenvatinib plus TACE with or without pembrolizumab for the treatment of initially unresectable hepatocellular carcinoma harbouring PD-L1 expression: a retrospective study
The aim of this retrospective study was to compare the clinical outcomes of pembrolizumab-lenvatinib-transarterial chemoembolization (TACE) versus lenvatinib-TACE sequential therapy in selected populations of ...
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Article
Dysregulation of alternative splicing contributes to multiple myeloma pathogenesis
Dysregulation of alternative splicing (AS) triggers many tumours, understanding the roles of splicing events during tumorigenesis would open new avenues for therapies and prognosis in multiple myeloma (MM).
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Article
Open AccessRestoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is the major histological subtype of kidney tumor which covers approximately 80% of the cases. Although various therapies have been developed, the clinical outcome rema...
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Article
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis
Ferroptosis, a nonapoptotic form of cell death marked by iron-dependent peroxidation of phospholipids, is associated with the occurrence and progression of tumors. Erastin, a selective inhibitor of the cystine...
