47 Result(s)
within
Wen** Peng
Biomedicine
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Article
Open AccesscircSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA
Lung cancer is the primary cause of cancer-related death worldwide, and its global incidence and mortality rates remain high. The differential expression of circular RNAs (circRNAs) can affect the development ...
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The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby contributing to the pathological remodeling of the joint. Semaphorins (...
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Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study
Following the short-term outbreak of Coronavirus disease 2019 (COVID-19) in December 2022 in China, clinical data on kidney transplant recipients (KTRs) with COVID-19 are lacking.
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Proteogenomic insights into early-onset endometrioid endometrial carcinoma: predictors for fertility-sparing therapy response
Endometrial carcinoma remains a public health concern with a growing incidence, particularly in younger women. Preserving fertility is a crucial consideration in the management of early-onset endometrioid endo...
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Open AccessDynamics of Cell Death Due to Electroporation Using Different Pulse Parameters as Revealed by Different Viability Assays
The mechanisms of cell death due to electroporation are still not well understood. Recent studies suggest that cell death due to electroporation is not an immediate all-or-nothing response but rather a dynamic...
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Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance
Cervical squamous cell carcinoma (CSCC) exhibits a limited response to immune-checkpoint blockade. Here we conducted a multiomic analysis encompassing single-cell RNA sequencing, spatial transcriptomics and sp...
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Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury
Circular RNAs are involved in intervention strategies for treating ischemic stroke (IS). However, circCNOT6L (hsa_circ_0006168) has not yet been reported in IS. Thus, we aimed to explore the potential role of ...
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Open AccessRecombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage
Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in a...
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Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol
Diabetes mellitus (DM) is a type of metabolic disease characterized by chronic hyperglycemia, which can lead to different degrees of cognitive decline. Therefore, it is crucial to explore the molecular biologi...
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Correction to: TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis
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Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?
为评估死亡供肾血栓和其诱导的受体血栓性微血管病(dir-TMA)对受体移植肾功能的影响, 我们回顾性分析了33例活检病理显示微血栓的供体信息及受体预后. 根据血栓累及肾小球范围是否大于50%, 将33例供体分为弥漫血栓组(n=18)和局灶血栓组(n=15). 结果显示, 弥漫血栓组的移植物延迟复功(DGF)发生率显著高于局灶血栓组(P=0.027), 肾移植术后1个月, 肾小球滤过率(eGFR)估值水**显著低于局灶血栓组...
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Open AccessMafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation fr...
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Correction to: MiR-139 Affects Radioresistance in Esophageal Cancer by Targeting the PDK1/AKT/Cyclin D1 Signaling Pathway
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Open AccessFibroblast-Conditioned Media Enhance the Yield of Microglia Isolated from Mixed Glial Cultures
Microglia are the main immune cells of the central nervous system (CNS) and comprise various model systems used to investigate inflammatory mechanisms in CNS disorders. Currently, shaking and mild trypsinizati...
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Open AccessRisk factors and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary-care hospital in China: an eight-year retrospective study
The prevalence of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) is increasing worldwide. CRKP-BSI is associated with high rates of morbidity and mortality due to limited antibiotic c...
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Open AccessAcetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
N4-acetylcytidine (ac4C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the translation process. However, the roles of both ac4C and its ‘writer’ protein N-a...
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Open AccessBiomechanical Analysis of the External Fixation in a Lumbar Fracture Model: A Finite Element Study
This study aimed to investigate the biomechanical characteristics of the external spinal fixation for treating lumbar fracture through finite element analysis (FEA) and provide a theoretical basis for its furt...
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Open AccessHydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway
After traumatic brain injury (TBI), an acute, robust inflammatory cascade occurs that is characterized by the activation of resident cells such as microglia, the migration and recruitment of peripheral immune ...
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Open AccessHigh complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis
Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial pneumonia. Lung cancer, mainly non-small cell lung cancer (NSCLC), is a complication of idiopathic pulmonary fibrosis. IPF is also an...
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Open AccessCirc-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK
Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, the biological functions of circRNAs and the underlying mec...
