7 Result(s)
within
WeiZhou Zhang
Biomedicine
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Article
Open AccessBody fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women
The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the asso...
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Chapter
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy
Regulatory T cells (Tregs) are critical in maintaining immune homeostasis under various pathophysiological conditions. A growing body of evidence demonstrates that Tregs play an important role in cancer progre...
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Article
Open AccessBody fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study
Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...
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Article
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as ABT263, as safe and effective antican...
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Article
Open AccessTop Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asy...
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Article
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
TLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ensuing immune...
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Article
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
Suppression of the kinase NIK prevents NF-κB signaling. The Cheng and Karin labs demonstrate that adaptor proteins TRAF2 and TRAF3 and ubiquitin ligases cIAP1 and cIAP2 regulate NIK degradation.
