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  1. No Access

    Article

    The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation

    Long non-coding RNAs (lncRNAs) have been identified as essential mediators in neurological dysfunction. Our previous study shows that berberine (BBR) hampers the nuclear-to-cytosolic translocation of high-mobi...

    Ding-wen Cao, Man-man Liu, Rui Duan, Yi-fu Tao, Jun-shan Zhou… in Acta Pharmacologica Sinica (2020)

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    Article

    Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation

    Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Berberine is a natural medicine with multiple beneficial biological activities...

    Jun-rong Zhu, Hai-dan Lu, Chao Guo, Wei-rong Fang… in Acta Pharmacologica Sinica (2018)