239 Result(s)
within
Wei-Guo **ao
Biomedicine
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Article
Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). However, due to the small number of patients, its...
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Open AccessCorrection: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
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Open AccessRecent progress of small-molecule of RET inhibitors against Non-small cell lung cancer
Since the oncogenic rearranged during transfection (RET) gene fusion was discovered in non-small cell lung cancer (NSCLC) in 2012, multiple-targeted kinase inhibitors (MKIs) cabozantinib and vandetanib have be...
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The recommendation of re-classification of variants of uncertain significance (VUS) in adult genetic disorders patients
Since variants of uncertain significance (VUS) reported in genetic testing cannot be acted upon clinically, this classification may delay or prohibit precise diagnosis and genetic counseling in adult genetic d...
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Correction: The role of H3K27me3 methylation in cancer development
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Caffeine: a potential mechanism for anti-obesity
Obesity refers to the excessive accumulation of fat caused by a long-term imbalance between energy intake (EI) and energy expenditure (EE). Over recent years, obesity has become a major public health challenge...
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Open AccessBrachytherapy in craniopharyngiomas: a systematic review and meta-analysis of long-term follow-up
Brachytherapy has been indicated as an alternative option for treating cystic craniopharyngiomas (CPs). The potential benefits of brachytherapy for CPs have not yet been clarified. The purpose of this work was...
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Identification of key gene expression associated with quality of life after recovery from COVID-19
Post-acute sequelae of COVID-19 (PASC) is a persistent complication of severe acute respiratory syndrome coronavirus 2 infection that includes symptoms, such as fatigue, cognitive impairment, and respiratory d...
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Impact of Cross-Limb Stent-Graft Configuration on Hemodynamics in Abdominal Aortic Aneurysm Interventional Therapy
The cross-limb (CL) technique is a commonly used endovascular treatment for addressing unfavorable anatomical features in patients with abdominal aortic aneurysm (AAA). The configuration of CL stent-graft play...
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Open AccessTumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis
The prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). ...
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Article
Exploring Prognostic Gene Factors in Breast Cancer via Machine Learning
Breast cancer remains the most prevalent cancer in women. To date, its underlying molecular mechanisms have not been fully uncovered. The determination of gene factors is important to improve our understanding...
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Open AccessThe efficacy and safety of vincristine, irinotecan and anlotinib in Epithelioid Sarcoma
Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are genera...
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MRE11 lactylation: new insight into DNA damage repair and tumorigenesis
The increased accumulation of lactate in tumor microenvironment is a characteristic feature of tumorigenesis, which affects various biological processes such as metabolism and immune response. The specific rol...
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The role of H3K27me3 methylation in cancer development
Although the importance of histone methylation in epigenetics was first suggested more than 50 years ago, research into histone modifications conducted in the past decade has led to an exponential increase in ...
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Open AccessDe novo identification of expressed cancer somatic mutations from single-cell RNA sequencing data
Identifying expressed somatic mutations from single-cell RNA sequencing data de novo is challenging but highly valuable. We propose RESA – Recurrently Expressed SNV Analysis, a computational framework to ident...
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Open AccessImpact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level is considered a predictive of AL, however, its impact on AL incidence ...
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Correction to: Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission
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H3K9me3 asymmetry: epigenetic choreography in DNA replication for genomic stability
Parental histones, which are modified distinctively from their newly synthesized counterparts, are recycled during DNA replication for the re-establishment of a functional epigenome in the daughter cells. Howe...
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Open AccessCorrection: LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGF R-2 signaling pathway in hepatocellular carcinoma
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Open AccessExploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02)
Novel and effective immunotherapies are required for refractory or recurrent sarcomas. Transforming growth factor-beta (TGF-β) is a diverse regulatory and fibrogenic protein expressed in multiple sarcoma tumo...
