175 Result(s)
within
Wei-**n Jiang
Internal Medicine
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Article
Carcinoembryonic antigen in monitoring of response to systemic chemotherapy in patients with metastatic colorectal cancer
The response to chemotherapy of solid tumors is generally assessed by measuring tumors visualized by imaging. However, the response assessment based on imaging is not always feasible because patients often hav...
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Article
Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2
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Lack of rebound of non-rapid eye movement sleep after sleep deprivation in adenosine A2A receptor knockout mice
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Molecular mechanism of prostaglandin D2-mediated non-REM sleep homeostasis studied by gene-knockout mice
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Metachronous colorectal cancer: necessity of post-operative colonoscopic surveillance
The aim of this study was to identify the occurrence and analyze the characteristics of metachronous colorectal cancers, and to compare the characteristics of these cases (index tumor) with the control group t...
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Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice
Although radiation can directly induce DNA damage and is a known human and animal carcinogen, the number of genetic changes in radiation-induced tumors, and the pathways responsible for generating them, are un...
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Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide
To investigate the effect of cholecystokinin octapeptide (CCK-8) on the diacylglycerol-protein kinase C (DAG-PKC) signaling pathway in rat pulmonary interstitial macrophages (PIM) stimulated by lipopolysaccari...
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Human low-density lipoprotein receptor gene and its regulation
The low-density lipoprotein (LDL) receptor is a transmembrane glycoprotein that mediates the binding and endocytosis of lipoproteins containing apolipoprotein B and E, especially the cholesterol-rich LDL. Muta...
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High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW264.7 cells
To investigate the protective effect of high density lipoprotein 3 (HDL3) on oxidized low density lipoprotein (ox-LDL)-induced apoptosis in RAW264.7 cells.
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LOH on chromosome 11q, but not SDHD and men1 mutations was frequently detectable in chinese patients with pheochromocytoma and paraganglioma
Recently, the succinate dehydrogenase subunit D (SDHD) gene has been reported as one of the major susceptibility genes for pheochromocytoma (PCC) and paraganglioma (PGL). In addition, loss of heterozygosity (LOH)...
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Article
Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP
To elucidate the effect and the mechanisms of curcumin on the expression of the human homeobox gene NKX3.1 in the prostate cancer cell LNCaP.
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Article
Gum mastic increases maspin expression in prostate cancer cells
To study whether gum mastic, a natural resin, can regulate maspin expression in prostate cancer cells, and further investigate the mechanisms involved in this regulatory system.
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p53 protein accumulation as a prognostic marker in sporadic colorectal cancer
p53 protein plays a crucial role in the pathogenesis of a large number of malignancies. In this study, our goal was to elucidate the prognostic role of p53 overexpression and its relationship to clinicopatholo...
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Low-dose carvedilol reduces transmural heterogeneity of ventricular repolarization in congestive heart failure
To study the effects of carvedilol on the transmural heterogeneity of ventricular repolarization in rabbits with congestive heart failure (CHF).
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Reversal of hyperglycemia by protein transduction of NeuroD in vivo
To test whether the neurogenic differentiation (NeuroD) protein could alleviate symptoms of diabetes mellitus by its transduction activity in vivo.
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Changes in disease pattern and treatment outcome of colorectal cancer: a review of 5,474 cases in 20 years
Colorectal cancer (CRC) is the third most common cause of cancer-related death in Taiwan. During the past 20 years, several advances have improved the treatment outcome and quality of life of CRC patients. The...
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Article
Increased levels of lipoprotein(a) in non-smoking aortic dissection patients
To investigate lipoprotein(a) (Lp(a)) serum levels in patients with aortic dissection and the influence of smoking on the level of Lp(a) in aortic dissection patients.
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Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells
Several β-subunits have been suggested to modulate the electrophysiological properties of the transient outward current (Ito) in cardiac myocytes, including the obligatory β-subunit K+-channel interacting protein...
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Article
High-throughput screening of novel antagonists on melanin-concentrating hormone receptor-1
To find new antagonists on human melanin-concentrating hormone receptor-1 (MCHR-1) through high-throughput screening (HTS) of a diverse compound library.
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Article
Open AccessPerioperative celecoxib administration for pain management after total knee arthroplasty – A randomized, controlled study
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. We evaluated opioid-sparing effects and rehabilitative results after perioperative celecoxib adminis...
