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2,685 Result(s)
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Article
Open AccessEnhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines
Enhancing influenza vaccine cross-protection is imperative to alleviate the significant public health burden of influenza. Heterologous sequential immunization may synergize diverse vaccine formulations and ro...
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Monomeric and self-assembled crystal phases of TNBT
(3,3′,5,5′-Tetranitro-4,4′-bi-1,2,4-Triazole) TNBT was designed and predicted more than three decades ago as a high energy material. As with many other designed molecules, TNBT has not been successfully synthe...
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Open AccessEffects of low-intensity pulsed ultrasound on the microorganisms of expressed prostatic secretion in patients with IIIB prostatitis
To detect and analyze the changes of microorganisms in expressed prostatic secretion (EPS) of patients with IIIB prostatitis before and after low-intensity pulsed ultrasound (LIPUS) treatment, and to explore t...
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Open AccessVirRep: a hybrid language representation learning framework for identifying viruses from human gut metagenomes
Identifying viruses from metagenomes is a common step to explore the virus composition in the human gut. Here, we introduce VirRep, a hybrid language representation learning framework, for identifying viruses ...
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Open AccessNBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...
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Open AccessPrevalence and quantity of lymph nodes at mediastinal stations in patients with lung cancer: lessons from 181 bilateral mediastinal lymphadenectomies
This study evaluated the prevalence and quantity of lymph nodes at particular stations of the mediastinum in patients with lung cancer. These data are important to radiologists, pathologists, and thoracic surg...
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Photothermal conversion property studies of polyoxophosphitemolybdate derivatives through microwave-assisted synthesis
Photothermal conversion is one of the key technologies in solar energy collection, seawater desalination, photothermal treatment and other important fields. In order to develop next generation photothermal mat...
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Selection dictates the distance pattern of similarity in trees and soil fungi across forest ecosystems
How the four major processes affecting community assembly—selection, dispersal, drift, and diversification—solely or jointly shape co-occurring assemblages of macro- and microorganisms at the same scales remai...
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SnO2/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage
Sn-based metal organic complexes with coordination bonds, multi-active sites, and high theoretical capacity have attracted much attention as promising anodes for lithium ion batteries. However, the low electri...
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Airways epithelial exposure to Streptococcus pneumoniae in the presence of the alarmin IL-33 induces a novel subset of pro-inflammatory ILC2s promoting a mixed inflammatory response
We have previously shown that asthma-like airways inflammation may be induced by topical exposure to respiratory tract pathogens such as S. pneumoniae (SP) in concert with epithelial alarmins such as IL-33. Detai...
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Open AccessNotoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...
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Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
The obesity paradox has been reported among older adults. However, whether the favorable effect of obesity is dependent on metabolic status remains largely unknown. We aimed to explore the association of metab...
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Open Access0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period
3% chloroprocaine (CP) has been reported as the common local anesthetic used in pregnant women undergoing urgent cesarean delivery during labor analgesia period. However, 0.75% ropivacaine is considered a prom...
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Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following thrombolysis and endovascular therapy. There is no approved drug in th...
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Machine learning guided efficiency improvement for Sn-based perovskite solar cells with efficiency exceeding 20%
Eco-friendly lead-free tin (Sn)-based perovskites have drawn much attention in the field of photovoltaics, and the highest power conversion efficiency (PCE) of Sn-based perovskite solar cells (PSCs) has been r...
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Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...
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Open AccessFractal analysis of left ventricular trabeculae in heart failure with preserved ejection fraction patients with multivessel coronary artery disease
Endocardial trabeculae undergo varicose changes and hyperplasia in response to hemodynamic influences and are a variable phenotype reflecting changes in disease. Fractal analysis has been used to analyze the c...
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Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Open AccessCorrection: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5Amediated chromatin accessibility