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  1. Article

    Open Access

    Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines

    Enhancing influenza vaccine cross-protection is imperative to alleviate the significant public health burden of influenza. Heterologous sequential immunization may synergize diverse vaccine formulations and ro...

    Chunhong Dong, Wandi Zhu, Lai Wei, Joo Kyung Kim, Yao Ma in Nature Communications (2024)

  2. No Access

    Article

    Monomeric and self-assembled crystal phases of TNBT

    (3,3′,5,5′-Tetranitro-4,4′-bi-1,2,4-Triazole) TNBT was designed and predicted more than three decades ago as a high energy material. As with many other designed molecules, TNBT has not been successfully synthe...

    Yun-Hui Wu, Hua-Bei You, Wei-Kai Cui, Zhi-Qian Cao, **ao Dong, Zi-Hui Meng in Rare Metals (2024)

  3. Article

    Open Access

    Effects of low-intensity pulsed ultrasound on the microorganisms of expressed prostatic secretion in patients with IIIB prostatitis

    To detect and analyze the changes of microorganisms in expressed prostatic secretion (EPS) of patients with IIIB prostatitis before and after low-intensity pulsed ultrasound (LIPUS) treatment, and to explore t...

    Wei-Jie Song, Ji-Wei Huang, Yuan Liu, Jie Wang, Wei Ding in Scientific Reports (2024)

  4. Article

    Open Access

    VirRep: a hybrid language representation learning framework for identifying viruses from human gut metagenomes

    Identifying viruses from metagenomes is a common step to explore the virus composition in the human gut. Here, we introduce VirRep, a hybrid language representation learning framework, for identifying viruses ...

    Yanqi Dong, Wei-Hua Chen, **ng-Ming Zhao in Genome Biology (2024)

  5. Article

    Open Access

    NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

    The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...

    Hengxing Chen, Yun Li, Huafu Li, **ancong Chen, Huafeng Fu, Deli Mao, Wei Chen in Nature (2024)

  6. Article

    Open Access

    Prevalence and quantity of lymph nodes at mediastinal stations in patients with lung cancer: lessons from 181 bilateral mediastinal lymphadenectomies

    This study evaluated the prevalence and quantity of lymph nodes at particular stations of the mediastinum in patients with lung cancer. These data are important to radiologists, pathologists, and thoracic surg...

    Łukasz Trybalski, Jakub Szadurski, Lanjun Zhang in Journal of Cardiothoracic Surgery (2024)

  7. No Access

    Article

    Photothermal conversion property studies of polyoxophosphitemolybdate derivatives through microwave-assisted synthesis

    Photothermal conversion is one of the key technologies in solar energy collection, seawater desalination, photothermal treatment and other important fields. In order to develop next generation photothermal mat...

    Mei-Qian Fu, Yu-Yang Han, Yan-Mei Nie, Yan-Di Liu, Yue Liu, Peng He in Rare Metals (2024)

  8. No Access

    Article

    Selection dictates the distance pattern of similarity in trees and soil fungi across forest ecosystems

    How the four major processes affecting community assembly—selection, dispersal, drift, and diversification—solely or jointly shape co-occurring assemblages of macro- and microorganisms at the same scales remai...

    Yue-Hua Hu, Daniel J. Johnson, Zhen-Hua Sun, Lian-Ming Gao in Fungal Diversity (2024)

  9. No Access

    Article

    SnO2/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage

    Sn-based metal organic complexes with coordination bonds, multi-active sites, and high theoretical capacity have attracted much attention as promising anodes for lithium ion batteries. However, the low electri...

    Gui-Long Liu, Zi-Han Zhao, **-Ke Shen, Zi-Bo Zhao, Nai-Teng Wu in Rare Metals (2024)

  10. No Access

    Article

    Airways epithelial exposure to Streptococcus pneumoniae in the presence of the alarmin IL-33 induces a novel subset of pro-inflammatory ILC2s promoting a mixed inflammatory response

    We have previously shown that asthma-like airways inflammation may be induced by topical exposure to respiratory tract pathogens such as S. pneumoniae (SP) in concert with epithelial alarmins such as IL-33. Detai...

    **aonan Du, Yan Li, Yingjie Xu, Yiran Yang, Chenduo Li, Yan Chen in Inflammation Research (2024)

  11. Article

    Open Access

    Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

    Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...

    Zhi-lun Yu, Rui-yang Gao, Cheng Lv, **ao-long Geng in Acta Pharmacologica Sinica (2024)

  12. No Access

    Article

    Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study

    The obesity paradox has been reported among older adults. However, whether the favorable effect of obesity is dependent on metabolic status remains largely unknown. We aimed to explore the association of metab...

    Wei-Qi Song, Wen-Fang Zhong, Jian Gao, Zhi-Hao Li in International Journal of Obesity (2024)

  13. Article

    Open Access

    0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period

    3% chloroprocaine (CP) has been reported as the common local anesthetic used in pregnant women undergoing urgent cesarean delivery during labor analgesia period. However, 0.75% ropivacaine is considered a prom...

    **n Men, Qian Wang, Jia-fu Dong, Pei Chen, **ao-xiao Qiu, Yin-qiu Han in BMC Anesthesiology (2024)

  14. No Access

    Article

    Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability

    The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following thrombolysis and endovascular therapy. There is no approved drug in th...

    **ao-ling Zhang, Wei-hong Du, Shu-xia Qian, Xu-dong Lu in Acta Pharmacologica Sinica (2024)

  15. No Access

    Article

    Machine learning guided efficiency improvement for Sn-based perovskite solar cells with efficiency exceeding 20%

    Eco-friendly lead-free tin (Sn)-based perovskites have drawn much attention in the field of photovoltaics, and the highest power conversion efficiency (PCE) of Sn-based perovskite solar cells (PSCs) has been r...

    Wei-Yin Gao, Chen-**n Ran, Liang Zhao, He Dong, Wang-Yue Li, Zhao-Qi Gao in Rare Metals (2024)

  16. Article

    Open Access

    Cholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma

    Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...

    Zi-Xun Yan, Yan Dong, Niu Qiao, Yi-Lun Zhang, Wen Wu, Yue Zhu in Nature Communications (2024)

  17. Article

    Open Access

    Fractal analysis of left ventricular trabeculae in heart failure with preserved ejection fraction patients with multivessel coronary artery disease

    Endocardial trabeculae undergo varicose changes and hyperplasia in response to hemodynamic influences and are a variable phenotype reflecting changes in disease. Fractal analysis has been used to analyze the c...

    Zi-Yi Gu, Bing-Hua Chen, Lei Zhao, Dong-Aolei An, Chong-Wen Wu in Insights into Imaging (2024)

  18. Article

    Open Access

    Landform and lithospheric development contribute to the assembly of mountain floras in China

    Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...

    Wan-Yi Zhao, Zhong-Cheng Liu, Shi Shi, Jie-Lan Li, Ke-Wang Xu in Nature Communications (2024)

  19. No Access

    Article

    Mendelian randomization evidence for the causal effect of mental well-being on healthy aging

    Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...

    Chao-Jie Ye, Dong Liu, Ming-Ling Chen, Li-Jie Kong, Chun Dou in Nature Human Behaviour (2024)

  20. Article

    Open Access

    Correction: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5Amediated chromatin accessibility

    Nan **g, **nxing Du, Yu Liang, ZhenKeke Tao in Journal of Experimental & Clinical Cancer … (2024)

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