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W **ong
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Article
Open AccessIsolation and characterisation of two epithelial-like cell lines from the gills of Chrysophrys auratus (Australasian snapper) and Oncorhynchus tshawytscha (Chinook salmon) and their use in aquatic toxicology
In vitro gill models are becoming increasingly important in aquatic toxicology, yet the fish gill invitrome is underrepresented, encompassing approximately 0.1% of extant species. Here, we describe the establi...
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Open AccessCorrection: Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity
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Open AccessModification of the Metallic Magnetic Calorimeter Fabrication Process for High Production Yield
We have modified the fabrication processes of metallic magnetic calorimeters (MMCs) to improve production yield. Key modifications include (i) the stress mitigation of the sputtered Nb film by optimizing the A...
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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
The use of modified nucleotides to suppress the interferon response and maintain translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet succeeded. We identify modified nucleo...
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Momentum for agroecology in the USA
Despite decades of resistance in the USA, agroecology is gaining momentum as a catalyst for food systems transformation, calling for coordinated action between science, practice and movement to dismantle the d...
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Research and development of time resolution and time reference adjustment for CMS improved resistive plate chambers (iRPCs)
Improved resistive plate chambers (iRPCs) will be installed in the challenging forward region of the compact muon solenoid (CMS) during its Phase-2 upgrade. The design target of iRPC time resolution is 1.5 ns....
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Effects of Bulleyaconitine A on Extracellular Matrix Secretion and Expression of Related Proteins in Acetaldehyde-Activated Hepatic Stellate Cells
Activated hepatic stellate cells differentiate into myofibroblasts, which synthesize and secrete extracellular matrix (ECM) leading to liver fibrosis. It was previously demonstrated that bulleyaconitine A (BLA...
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Correction: Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults
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Outcomes of Rituximab-abbs versus Rituximab in Patients with Diffuse Large B-Cell Lymphoma in a Noninferiority Study
Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is one of the first line treatments for diffuse large B-cell lymphoma (DLBCL). Rituximab comprises most of the treatment cost ...
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Open AccessLoss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how these mutations may shape epigenomic and transcrip...
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Open AccessCumulative Benefit Over 52 Weeks With Deucravacitinib Versus Apremilast in Moderate to Severe Plaque Psoriasis: POETYK PSO-1 Post Hoc Analysis
Deucravacitinib demonstrated superior efficacy to apremilast in patients with moderate to severe plaque psoriasis in the POETYK PSO-1 and PSO-2 clinical trials. In the study reported here, we aimed to determin...
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Open AccessPredicting Abrocitinib Efficacy at Week 12 Based on Clinical Response at Week 4: A Post Hoc Analysis of Four Randomized Studies in Moderate-to-Severe Atopic Dermatitis
Early prediction of abrocitinib efficacy in atopic dermatitis (AD) could help identify candidates for an early dose increase. A predictive model determined week 12 efficacy based on week 4 responses in patient...
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Implantable Devices in Otolaryngology: Pediatric Application of Active Bone Conduction Devices
This review offers insights into Active Transcutaneous Bone Conduction Implants (ATBCI) for pediatric patients with hearing loss, emphasizing the latest discoveries.
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Mirror-image cyclodextrins
For over a century, naturally occurring cyclodextrins (CDs) have been investigated intensively and extensively. CDs possess inherently stable chiralities, which render them versatile players in diverse arenas ...
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Open AccessA novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells
BAX and BAK are pro-apoptotic members of the BCL2 family that are required to permeabilize the mitochondrial outer membrane. The proteins can adopt a non-activated monomeric conformation, or an activated confo...
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Open AccessIxekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity
Skin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective interleukin (IL)-17A antagonist, was compared to placebo (PBO) in the SPIRI...
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Targetable leukaemia dependency on noncanonical PI3Kγ signalling
Phosphoinositide-3-kinase-γ (PI3Kγ) is implicated as a target to repolarize tumour-associated macrophages and promote antitumour immune responses in solid cancers1–4. However, cancer cell-intrinsic roles of PI3Kγ...
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A Novel Method for Testing and Evaluating the Fatigue Life of Metal Vibration Absorber
Metal vibration absorber has been widely used to reduce the structural vibration under various complex environmental conditions, the fatigue reliability of which has an important influence on the safety of the...
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Open AccessBiomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings
The focus of medicine is shifting from treatment to preventive care. The expression of biomarkers of dementia and Alzheimer’s disease (AD) appear decades before the onset of observable symptoms, and evidence h...
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Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults
Many studies have examined the relationship between plasma metabolites and type 2 diabetes progression, but few have explored saliva and multi-fluid metabolites.
