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Article

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis

Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain not fully understood. Surprisi...

Chantal Alkhoury, Nathaniel F. Henneman, Volodymyr Petrenko… in Nature Cell Biology (2023)