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  1. Article

    Open Access

    Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

    Alzheimer’s disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinn...

    Benjamin J. Kim, Vivian Lee, Edward B. Lee… in Acta Neuropathologica Communications (2021)

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  2. No Access

    Article

    Multiscale reverse engineering of the human ocular surface

    Here we present a miniaturized analog of a blinking human eye to reverse engineer the complexity of the interface between the ocular system and the external environment. Our model comprises human cells and pro...

    Jeongyun Seo, Woo Y. Byun, Farid Alisafaei, Andrei Georgescu… in Nature Medicine (2019)

  3. No Access

    Article

    Reproductible production of a PEGylated dual-acting peptide for diabetes

    A pEGylated glucagon-like peptide-1 (GLP-1) agonist and glucagon antagonist hybrid peptide was engineered as a potential treatment for type 2 diabetes. To support preclinical development of this PEGylated dual...

    Irene Tom, Vivian Lee, Michael Dumas, Melanie Madanat, Jun Ouyang… in The AAPS Journal (2007)

  4. Article

    Open Access

    GOAnnotator: linking protein GO annotations to evidence text

    Annotation of proteins with gene ontology (GO) terms is ongoing work and a complex task. Manual GO annotation is precise and precious, but it is time-consuming. Therefore, instead of curated annotations most o...

    Francisco M Couto, Mário J Silva, Vivian Lee… in Journal of Biomedical Discovery and Collab… (2006)

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