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  1. Article

    Open Access

    Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

    Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to ...

    Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo… in Nature Communications (2017)

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