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  1. No Access

    Article

    Administration of α-lipoic acid and silymarin attenuates aggression by modulating endocrine, oxidative stress and inflammatory pathways in mice

    Aggression, a highly prevalent behavior among all the psychological disorders having strong association with psychiatric imbalance, neuroendocrine changes and neurological disturbances (including oxidative str...

    Adnan Karim, Fareeha Anwar, Uzma Saleem, Saniya Fatima… in Metabolic Brain Disease (2023)

  2. No Access

    Article

    The curative and mechanistic acumen of curcuminoids formulations against haloperidol induced Parkinson’s disease animal model

    Parkinson’s disease (PD) is slowly develo** neurodegenerative disorder associated with gradual decline in cerebration and laboriousness to perform routine piece of work. PD imposed a social burden on society...

    Uzma Saleem, Sundas Khalid, Zunera Chauhdary, Fareeha Anwar… in Metabolic Brain Disease (2023)

  3. No Access

    Article

    Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis

    Mangifera indica L., also known as mango, is a tropical fruit that belongs to the Anacardiaceae family and is prized for its juiciness, unique flavour, and worldwide popularity. The current study aimed to probe i...

    Uzma Saleem, Shafa Iman, Bashir Ahmad, Muhammad Ajmal Shah… in Metabolic Brain Disease (2023)

  4. No Access

    Article

    Sarcococca saligna ameliorated D-galactose induced neurodegeneration through repression of neurodegenerative and oxidative stress biomarkers

    Sarcococca saligna is a valuable source of bioactive secondary metabolites exhibiting antioxidant, anti-inflammatory and acetylcholinesterase inhibitory activities. The study was intended to explore the therapeut...

    Uzma Saleem, Zunera Chauhdary, Sumera Islam, Aimen Zafar… in Metabolic Brain Disease (2023)

  5. No Access

    Article

    Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism

    Cucurbita pepo is used as a vegetable in Pakistan and its seeds are also rich in tocopherol. Data showed the pivotal role of tocopherol in the treatment of Parkinson’s disease (PD). The current study was designed...

    Uzma Saleem, Aisha Shehzad, Shahid Shah, Zohaib Raza… in Metabolic Brain Disease (2021)

  6. No Access

    Article

    Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer’s Disease in Mice

    Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with decline in memory and cognitive impairments. Phosphodiesterase IV (PDE4) protein, an intracellular cAMP levels regulator, whe...

    Samra Nazir, Fareeha Anwar, Uzma Saleem, Bashir Ahmad… in Neurochemical Research (2021)

  7. No Access

    Article

    Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers

    Alzheimer’s disease affects daily routine due to loss of memory and decline in cognition. In vitro data showed acetylcholine esterase inhibition activity of Malva neglecta but no in vivo evidence is available. Th...

    Uzma Saleem, Rubina Akhtar, Fareeha Anwar, Muhammad Ajmal Shah… in Metabolic Brain Disease (2021)

  8. No Access

    Article

    Screening of Synthetic Isoxazolone Derivative Role in Alzheimer’s Disease: Computational and Pharmacological Approach

    Alzheimer's disease (AD) is age-dependent neurological disorder with progressive loss of cognition and memory. This multifactorial disease is characterized by intracellular neurofibrillary tangles, beta amyloi...

    Meissam Ali, Uzma Saleem, Fareeha Anwar, Muhammad Imran… in Neurochemical Research (2021)

  9. No Access

    Article

    Exploring the Therapeutic Potentials of Highly Selective Oxygenated Chalcone Based MAO-B Inhibitors in a Haloperidol-Induced Murine Model of Parkinson’s Disease

    Parkinson’s disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the developmen...

    Della Grace Thomas Parambi, Uzma Saleem, Muhammad Ajmal Shah… in Neurochemical Research (2020)