22 Result(s)
within
Tracey A. Rouault
English
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Article
An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein
Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element bin...
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Article
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
In mammalian cells, regulation of the expression of proteins involved in iron metabolism is achieved through interactions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts tha...
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Article
Iron on the brain
Accumulations of iron are often detected in the brains of people suffering from neurodegenerative diseases. But it is often not known whether such accumulations contribute directly to disease progression. The ...
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Chapter
Post-Transcriptional Regulation of Iron Metabolism
Over the last fifteen years, much insight has been gained into the processes that determine how iron will be transported and utilized in cells and animals. Regulation of iron metabolism is important because ir...
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Article
Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2
The ubiquitin system is involved in several basic cellular functions1,2,3. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes. Among these, the E3 ubiquitin–prote...
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Article
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formatio...
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Article
Linking physiological functions of iron
Iron-sulfur clusters and hemes are two iron-containing prosthetic groups involved in important physiological functions. Identification of the gene responsible for anemia in a mutant zebrafish has revealed an u...
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Article
The role of iron regulatory proteins in mammalian iron homeostasis and disease
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular ...
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Article
Reply to “Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse”
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Article
Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis
Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochon...
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Article
Serum ferritin concentrations in Africans with low dietary iron
In the setting of high dietary, several studies have provided evidence for a strong effect of both high dietary iron and an unidentified genetic locus on iron stores in Africans. To investigate whether these e...
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Article
Open AccessBrain iron homeostasis, the choroid plexus, and localization of iron transport proteins
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron...
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Open AccessAberrant iron homeostasis, oxidative fiber enrichment, and activation of ketogenesis in muscle tissue of ISCU Myopathy patients
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Article
Open AccessInsertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron–sulfur cluster enzyme activities and impaired iron homeostasis
Despite the prominence of iron–sulfur cluster (ISC) proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, these proteins have been given sc...
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Article
Iron metabolism in the CNS: implications for neurodegenerative diseases
Iron homeostasis in the CNS operates in parallel with systemic iron homeostasis, because iron must cross the blood–brain barrier or blood–cerebrospinal fluid b...
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Article
Mammalian iron–sulphur proteins: novel insights into biogenesis and function
Iron–sulphur (Fe–S) clusters are flexible cofactors composed of iron and inorganic sulphur that are often ligated to proteins through cysteinyl ligands.
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Iron-sulfur proteins hiding in plain sight
Recent studies suggest that iron-sulfur (Fe-S) proteins may be unexpectedly abundant and functionally diverse in mammalian cells, but their identification still remains difficult. The use of informatics along ...
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Article
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke–induced chronic obstructive pulmonary disease in mice.
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Article
Open AccessTumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, ...
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Article
Open AccessThe indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
In recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently ...
