7 Result(s)

Article

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that N...

Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity… in Nature Communications (2023)

Article

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine macrophages is...

Erika M. Palmieri, Marieli Gonzalez-Cotto, Walter A. Baseler… in Nature Communications (2020)

Article

The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways

In recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently ...

Tracey A. Rouault in BioMetals (2019)

Article

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, ...

Christopher M. Rice, Luke C. Davies, Jeff J. Subleski… in Nature Communications (2018)

Article

Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron–sulfur cluster enzyme activities and impaired iron homeostasis

Despite the prominence of iron–sulfur cluster (ISC) proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, these proteins have been given sc...

Helge Uhrigshardt, Tracey A. Rouault… in JBIC Journal of Biological Inorganic Chemi… (2013)

Article

Aberrant iron homeostasis, oxidative fiber enrichment, and activation of ketogenesis in muscle tissue of ISCU Myopathy patients

Daniel R Crooks, Thanemozhi G Natarajan, Churning Chen, Hongzhan Huang… in BMC Proceedings (2012)

Article

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron...

Tracey A. Rouault, De-Liang Zhang, Suh Young Jeong in Metabolic Brain Disease (2009)