7 Result(s)
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Article
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke–induced chronic obstructive pulmonary disease in mice.
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Article
Mammalian iron–sulphur proteins: novel insights into biogenesis and function
Iron–sulphur (Fe–S) clusters are flexible cofactors composed of iron and inorganic sulphur that are often ligated to proteins through cysteinyl ligands.
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Article
Reply to “Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse”
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Article
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formatio...
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Article
Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2
The ubiquitin system is involved in several basic cellular functions1,2,3. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes. Among these, the E3 ubiquitin–prote...
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Iron on the brain
Accumulations of iron are often detected in the brains of people suffering from neurodegenerative diseases. But it is often not known whether such accumulations contribute directly to disease progression. The ...
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Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
In mammalian cells, regulation of the expression of proteins involved in iron metabolism is achieved through interactions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts tha...
