7 Result(s)
-
Article
Open AccessThe indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
In recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently ...
-
Article
Mammalian iron–sulphur proteins: novel insights into biogenesis and function
Iron–sulphur (Fe–S) clusters are flexible cofactors composed of iron and inorganic sulphur that are often ligated to proteins through cysteinyl ligands.
... -
Article
Open AccessInsertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron–sulfur cluster enzyme activities and impaired iron homeostasis
Despite the prominence of iron–sulfur cluster (ISC) proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, these proteins have been given sc...
-
Article
Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis
Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochon...
-
Article
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formatio...
-
Article
Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2
The ubiquitin system is involved in several basic cellular functions1,2,3. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes. Among these, the E3 ubiquitin–prote...
-
Article
An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein
Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element bin...
