7 Result(s)
within
Tracey A. Rouault
Biomedicine
English
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Article
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke–induced chronic obstructive pulmonary disease in mice.
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Article
Iron metabolism in the CNS: implications for neurodegenerative diseases
Iron homeostasis in the CNS operates in parallel with systemic iron homeostasis, because iron must cross the blood–brain barrier or blood–cerebrospinal fluid b...
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Article
Open AccessBrain iron homeostasis, the choroid plexus, and localization of iron transport proteins
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron...
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Article
Reply to “Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse”
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Chapter
Post-Transcriptional Regulation of Iron Metabolism
Over the last fifteen years, much insight has been gained into the processes that determine how iron will be transported and utilized in cells and animals. Regulation of iron metabolism is important because ir...
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Article
Iron on the brain
Accumulations of iron are often detected in the brains of people suffering from neurodegenerative diseases. But it is often not known whether such accumulations contribute directly to disease progression. The ...
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Article
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
In mammalian cells, regulation of the expression of proteins involved in iron metabolism is achieved through interactions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts tha...
