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Article
Open AccessGefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer
A prospective, multicenter, large-scale cohort with a nested case–control study (NCT00252759) was conducted to identify and quantify risk factors for interstitial lung disease (ILD) in Japanese patients with n...
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Article
Open AccessSafety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours
This was the first Phase I study to assess the safety and tolerability of the tablet formulation of olaparib (Lynparza™), an oral poly(ADP-ribose) polymerase inhibitor, in Japanese patients with advanced solid...
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Article
Open AccessSafety and tolerability of AZD5363 in Japanese patients with advanced solid tumors
Investigate the safety and tolerability of AZD5363 and define a recommended dose for evaluation in Japanese patients with advanced solid malignancies.