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  1. No Access

    Article

    Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model

    Boron neutron capture therapy (BNCT) is a binary cancer treatment that combines boron administration and neutron irradiation. The tumor cells take up the boron compound and the subsequent neutron irradiation r...

    Tsubasa Watanabe, Tomohiro Yoshikawa… in European Journal of Drug Metabolism and Ph… (2023)

  2. No Access

    Article

    In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol

    In this study, we demonstrated the in vitro and in vivo antiherpetic activities of a stable furan derivative, (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol (MFPT), which had originally been isolated from Stre...

    Kohei Sasaki, Kyoko Hayashi, Yuji Matsuya, Kenji Sugimoto… in Journal of Natural Medicines (2016)

  3. No Access

    Article

    Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

    In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (...

    Lamjed Bouslama, Kyoko Hayashi, Jung-Bum Lee… in Journal of Natural Medicines (2011)

  4. No Access

    Article

    Two new monoterpenes from Sibiraea angustata

    Two novel monoterpenes, sibiscolacton (1) and sibiraic acid (2), were isolated from the aerial part of Sibiraea angustata Rchd. along with seven known compounds, namely three phenylpropanoids (3–5), two flavonoid...

    Bin Li, Jung-Bum Lee, Kyoko Hayashi, Yoshiaki Ito… in Journal of Natural Medicines (2010)