-
Article
Open AccessMCPIP1 functions as a safeguard of early embryonic development
Monocyte chemoattractant protein-induced protein 1 (MCPIP1), also called Regnase-1, is an RNase that has been described as a key negative modulator of inflammation. MCPIP1 also controls numerous tumor-related ...
-
Article
Human skin commensals augment Staphylococcus aureus pathogenesis
All bacterial infections occur within a polymicrobial environment, from which a pathogen population emerges to establish disease within a host. Emphasis has been placed on prevention of pathogen dominance by c...
-
Protocol
Construction and Use of Staphylococcus aureus Strains to Study Within-Host Infection Dynamics
The study of the dynamics that occur during the course of a bacterial infection has been attempted using several methods. Here we discuss the construction of a set of antibiotic-resistant, otherwise-isogenic Stap...
-
Protocol
Use of Larval Zebrafish Model to Study Within-Host Infection Dynamics
Investigating bacterial dynamics within the infected host has proved very useful for understanding mechanisms of pathogenesis. Here we present the protocols we use to study bacterial dynamics within infected e...
-
Article
Open AccessRNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum
The Gram-positive bacterium Enterococcus faecium is a commensal of the human gastrointestinal tract and a frequent cause of bloodstream infections in hospitalized patients. The mechanisms by which E. faecium can ...
-
Article
Open AccessZebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases
Porphyromonas gingivalis (Pg) is a keystone pathogen in the aetiology of chronic periodontitis. However, recent evidence suggests that the bacterium is also able to enter the bloodstream, interact with host cells...
