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Article
Open AccessOver-expression of miR-34c leads to early-life visceral fat accumulation and insulin resistance
Overweight children and adolescents are at high risk for adult and late life obesity. This report investigates some underlying mechanisms contributing to obesity during early life in an animal model. We genera...
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Article
Open AccessInflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes
Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell communication by exporting encapsulated materials, such as microRNAs (miRNAs), to target cells. Endothelial cell-der...
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Chapter
Mouse Models of Human Trisomy 21 (Down Syndrome)
Trisomy 21 is one of the most frequent chomosome abnormalities in man. One out of 700 to 1000 newborn babies has this chromosomal imbalance, which arises due to meiotic nondisjunction of chromosome 21. This le...