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  1. Article

    Open Access

    Over-expression of miR-34c leads to early-life visceral fat accumulation and insulin resistance

    Overweight children and adolescents are at high risk for adult and late life obesity. This report investigates some underlying mechanisms contributing to obesity during early life in an animal model. We genera...

    Philip H. Jones, Brian Deng, Jessica Winkler, Arin L. Zirnheld in Scientific Reports (2019)

  2. Article

    Open Access

    Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

    Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell communication by exporting encapsulated materials, such as microRNAs (miRNAs), to target cells. Endothelial cell-der...

    Seiji Yamamoto, Shumpei Niida, Erika Azuma, Tsutomu Yanagibashi in Scientific Reports (2015)

  3. No Access

    Chapter

    Mouse Models of Human Trisomy 21 (Down Syndrome)

    Trisomy 21 is one of the most frequent chomosome abnormalities in man. One out of 700 to 1000 newborn babies has this chromosomal imbalance, which arises due to meiotic nondisjunction of chromosome 21. This le...

    Christoph N. Berger, Ting-Ting Huang in Genetically Defined Animal Models of Neuro… (1992)