164 Result(s)
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Highly efficient photo-thermal synergistic catalysis of CO2 methanation over La1−xCexNiO3 perovskite-catalyst
Solar-driven photo-thermal catalytic CO2 methanation reaction is a promising technology to alleviate the problems posed by greenhouse gases emissions. However, designing advanced photo-thermal catalysts remains a...
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Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics
Genome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially power loss due to p...
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A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine ...
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Designing multi-heterogeneous interfaces of Ni-MoS2@NiS2@Ni3S2 hybrid for hydrogen evolution
The transition metal chalcogenides represented by MoS2 are the ideal choice for non-precious metal-based hydrogen evolution catalysts. However, whether in acidic or alkaline environments, the catalytic activity o...
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Slow-Reflow and Prognosis in Patients with High Parathyroid Hormone Levels Undergoing Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction
We aimed to evaluate the correlation among serum parathyroid hormone (PTH) and slow-reflow during primary percutaneous coronary intervention (PCI) and prognosis in patients with ST-segment elevation myocardial...
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Omics-based molecular classifications empowering in precision oncology
In the past decades, cancer enigmatical heterogeneity at distinct expression levels could interpret disparities in therapeutic response and prognosis. It built hindrances to precision medicine, a tactic to tai...
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Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model
Prostate cancer (PCa) is the second most prevalent malignancy among men worldwide. The aberrant activation of androgen receptor (AR) signaling has been recognized as a crucial oncogenic driver for PCa and AR a...
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Open AccessThe deubiquitinating enzyme USP4 regulates BRCA1 stability and function
BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified...
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Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Diabetes mellitus results in numerous complications. Diabetic pulmonary fibrosis (DPF), a late pulmonary complication of diabetes, has not attracted as much attention as diabetic nephropathy and cardiomyopathy...
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Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease that is substantially associated with obesity-induced chronic inflammation. Macrophage activation and macrophage-medicated inflammation p...
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Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
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Open AccessMini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial
There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel...
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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis
Efforts to advance RNA aptamers as a new therapeutic modality have been limited by their susceptibility to degradation and immunogenicity. In a previous study, we demonstrated synthesized short double-stranded...
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miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be delivered into recipient cells in cell biological processes. Here, we examined microRNA (miRNA) expression i...
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Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts
Develo** electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) is of considerable importance for the industrial prod...
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Enhanced carbon capture with motif-rich amino acid loaded defective robust metal-organic frameworks
The use of metal-organic frameworks (MOFs) as solid adsorption materials for carbon capture is promising, but achieving efficient and reversible adsorption with a balance of capacity and selectivity for carbon...
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First-line sugemalimab with chemotherapy for advanced esophageal squamous cell carcinoma: a randomized phase 3 study
Although antiprogrammed death 1 antibody plus chemotherapy has recently been approved for first-line esophageal squamous cell carcinoma (ESCC), antiprogrammed death-ligand 1 antibody may offer another combinat...
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Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance
Artificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to light pollution. Exacerbating this issue, artificially lit o...
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Open AccessGenetics and pathologic landscape of lineage switch of acute leukemia during therapy
