58 Result(s)

Article

Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers

The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (d...

Zhenghang Wang, Siyuan Cheng, Yanhong Yao, Shengde Liu… in Cancer Immunology, Immunotherapy (2024)

Article

HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...

Ya-juan Guo, **g-**g Yao, Zhen-zhen Guo, Ming Ding… in Acta Pharmacologica Sinica (2024)

Article

Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, **n Xu… in Acta Pharmacologica Sinica (2024)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway

As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using pati...

Yi-Bo Wu, Shen-Yi Li, **-Yan Liu, Jia-Jia Xue, **-Fu Xu… in Cell Death & Disease (2023)

Article

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m⁶A-dependent manner

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...

Li-Jie Chen, Hui-Ye Liu, Zhi-Yuan **ao, Ting Qiu, Dan Zhang… in Cell Death & Disease (2023)

Article

A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer

Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular prolif...

Ting Wang, Yi Qin, Zeng Ye, De-sheng **g, Gui-xiong Fan… in Acta Pharmacologica Sinica (2023)

Article

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Lymphatic metastasis is the most common pattern of bladder cancer (BCa) metastasis and has an extremely poor prognosis. Emerging evidence shows that ubiquitination plays crucial roles in various processes of t...

Kanghua **ao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong… in Cell Death & Disease (2023)

Article

Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8⁺-T cell immunity

The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the...

Feng Liu, Qian Zhou, Hai-feng Jiang… in Journal of Experimental & Clinical Cancer … (2023)

Article

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis

Metformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy in restoring blood lipids and liver histology have been contr...

Bingli Liu, **gyuan Xu, Linyao Lu, Lili Gao, Shengjuan Zhu, Yi Sui… in Cell Death & Disease (2023)

Article

Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

The type I cGMP-dependent protein kinase (PKG I) is recognized as a tumor suppressor, but its role in EGFR regulated epithelial ovarian cancer (EOC) progression remains unclear. We evaluated the in vivo and in...

Ting Lan, Ying Li, Yue Wang, Zhong-Cheng Wang, Chun-Yan Mu… in Cell Death & Disease (2023)

Article

Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays

Synthetic glucocorticoids (GCs) have been widely used in the treatment of a broad range of inflammatory diseases, but their clinic use is limited by undesired side effects such as metabolic disorders, osteopor...

**-** Pang, Xue-** Hu, Yun-xia Wang, Jia-ning Liao… in Acta Pharmacologica Sinica (2022)

Article

LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma

Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood. With the increas...

Yanliang Wang, Yu Chen Feng, Yu** Gan… in Journal of Experimental & Clinical Cancer … (2022)

Article

Epstein–Barr virus-encoded microRNA BART22 serves as novel biomarkers and drives malignant transformation of nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy ubiquitously associated with Epstein–Barr virus (EBV). EBV generates various viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (B...

Ting Zhang, Zui Chen, **g Deng, Kaixiong Xu, Di Che, Jiamin Lin… in Cell Death & Disease (2022)

Article

Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening

Primary cilia dyskinesia (PCD) is a rare genetic disease caused by ciliary structural or functional defects. It causes severe outcomes in patients, including recurrent upper and lower airway infections, progre...

Rui Zheng, Wenhao Yang, Yuting Wen, Liang **e, Fang Shi, Danli Lu… in Cell Death & Disease (2022)

Article

Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

The adaption of brain region is fundamental to the development and maintenance of nervous system disorders. The prelimbic cortex (PrL) participates in the affective components of the pain sensation. However, w...

Yu-Ting Zhao, Jie Deng, He-Ming Liu, Jia-You Wei… in Journal of Neuroinflammation (2022)

Article

CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition

Circular RNAs (circRNAs) belong to an abundant category of non-coding RNAs that are stable and specific, and thus have great potential in cancer treatment. However, little is known about the role of circRNAs d...

Ting Zhang, Dong-Ming Wu, Peng-Wei Luo, Teng Liu, Rong Han… in Cell Death & Disease (2022)

Article

ALCAM regulates multiple myeloma chemoresistant side population

Drug-resistance is a major problem preventing a cure in patients with multiple myeloma (MM). Previously, we demonstrated that activated-leukocyte-cell-adhesion-molecule (ALCAM) is a prognostic factor in MM and...

Fangfang Wang, Zhang Dan, Hongmei Luo, **gcao Huang, Yushan Cui… in Cell Death & Disease (2022)

Article

Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice

Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in ...

Fu Li, Haitao **ang, Yue Gu, Ting Ye, Xu Lu, Chao Huang in Journal of Neuroinflammation (2022)

Article

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1

Immune checkpoint inhibition is an important strategy in cancer therapy. Blockade of CTLA-4 and PD-1/PD-L1 is well developed in clinical practice. In the last few years, LAG-3 has received much interest as an ...

Wan-ting Zhang, Ting-ting Liu, Man Wu, **ao-chen Chen, Li Han… in Acta Pharmacologica Sinica (2021)