23 Result(s)

Article

Mini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial

There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel...

Yu Wang, Qi-Fa Liu, De-Pei Wu, Zheng-Li Xu, Ting-Ting Han, Yu-Qian Sun… in BMC Medicine (2024)

Article

Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation

To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats.

Lan-Chun Zhang, Na Li, Min Xu, Ji-Lin Chen, Hua He… in European Journal of Medical Research (2024)

Article

Self- and interviewer-reported cognitive problems in relation to cognitive decline and dementia: results from two prospective studies

Little is known regarding the association of interviewer-reported cognitive problems (ICP) with age-related cognitive decline. We aimed to investigate the independent associations of ICP and the combined assoc...

Yuhui Huang, Hui Chen, Mengyan Gao, **aozhen Lv, Ting Pang, Shuang Rong… in BMC Medicine (2024)

Article

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has revealed the implication of...

Hong** Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan… in BMC Medicine (2024)

Article

Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns

This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring the association between structural alterations and molecular mechanisms using a combined...

Guanqun Yao, Ting Zou, **g Luo, Shuang Hu, Langxiong Yang, **g Li… in BMC Medicine (2023)

Article

Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study

AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies. Herein, the pharmacokinetics (PK), saf...

Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang… in BMC Medicine (2023)

Article

Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study

As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning research has progressed in this field. However, there is a scarcity of literature specific...

Yao-Ge Liu, Shi-Tao Jiang, Lei Zhang, Han Zheng… in European Journal of Medical Research (2023)

Article

Identifying the causal effects of long-term exposure to PM_2.5 and ground surface ozone on individual medical costs in China—evidence from a representative longitudinal nationwide cohort

There is little evidence on whether PM_2.5 and ground surface ozone have consistent effects on increased individual medical costs, and there is a lack of evidence on causality in develo** countries.

Ke Ju, Liyong Lu, **gguo Yang, Ting Chen, Tianjiao Lan, Zhongxin Duan… in BMC Medicine (2023)

Article

SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

Aberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit guidance ligand 2 (SLIT2) promoter methylation was associated with disease prog...

De-long Wu, Yun Wang, Ting-juan Zhang… in European Journal of Medical Research (2022)

Article

Association of dynamic changes in serum levels of HBV DNA and risk of hepatocellular carcinoma

We aimed to examine the risk of HCC associated with the long-term change patterns in HBV DNA levels.

**n Xu, Jie Jiang, Ci Song, Chengxiao Yu, Liguo Zhu, Jiao Qian… in Current Medicine (2022)

Article

Author Correction: Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Fei Li, Di** Song, Han Chen, Jian **ong, **ngyi Li, Hua Zhong… in npj Digital Medicine (2022)

Article

YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial

Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathological mechanisms of liver fibrosis are comp...

Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-Hui Zhou… in Trials (2021)

Article

One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection

Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospit...

Yanfei Chen, Cheng Ding, Ling Yu, Wanru Guo, Xuewen Feng, Liang Yu… in BMC Medicine (2021)

Article

Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome

Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabol...

Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong… in BMC Medicine (2021)

Article

Dietary fruit and vegetable intake, gut microbiota, and type 2 diabetes: results from two large human cohort studies

Little is known about the inter-relationship among fruit and vegetable intake, gut microbiota and metabolites, and type 2 diabetes (T2D) in human prospective cohort study. The aim of the present study was to i...

Zengliang Jiang, Ting-yu Sun, Yan He, Wanglong Gou, Luo-shi-yuan Zuo… in BMC Medicine (2020)

Article

Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

By 2040, ~100 million people will have glaucoma. To date, there are a lack of high-efficiency glaucoma diagnostic tools based on visual fields (VFs). Herein, we develop and evaluate the performance of ‘iGlauco...

Fei Li, Di** Song, Han Chen, Jian **ong, **ngyi Li, Hua Zhong… in npj Digital Medicine (2020)

Article

Efficacy and safety of YinQiSanHuang-antiviral decoction in chronic hepatitis B: study protocol for a randomized, placebo-controlled, double-blinded trial

Chronic hepatitis B (CHB) is a global public health problem. Antiviral therapy is the primary treatment. Studies have shown that a combined therapy of traditional Chinese medicine (TCM) and conventional antivi...

Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-hui Zhou… in Trials (2020)

Article

Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births

In 2005, the FDA cautioned that exposure to paroxetine, a selective serotonin reuptake inhibitor (SSRI), during the first trimester of pregnancy may increase the risk of cardiac malformations. Since then, the ...

Shan-Yan Gao, Qi-Jun Wu, Ce Sun, Tie-Ning Zhang, Zi-Qi Shen, Cai-**a Liu… in BMC Medicine (2018)