8 Result(s)
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Ting Ting Liu
Cancer Research
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Article
Open AccessP2X7 receptor: a potential target for treating comorbid anxiety and depression
In clinical practice, depression and anxiety frequently coexist, and they are both comorbid with somatic diseases. The P2X7R is an adenosine 5’-triphosphate (ATP)-gated non-selective cation channel that is wid...
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Article
Open AccessThe prognostic significance of histologic variant on survival outcomes in patients with metastatic urothelial carcinoma receiving immune checkpoint inhibitor therapy
While the treatment guidelines have been established for pure urothelial carcinoma (pUC), patients with variant type urothelial carcinoma (vUC) face limited effective treatment options. The effectiveness of im...
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Article
Open AccessATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Autophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in cancer progression. Phosphorylation of ATG4B is crucial for activation of its protease ac...
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Article
Open AccessP2Y12 receptor gene polymorphisms are associated with epilepsy
The basic research indicated that microglial P2Y12 receptors (P2Y12Rs) are involved in the pathophysiology of epilepsy through regulated microglial-neuronal interactions, aberrant neurogenesis, or immature neuron...
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Article
Open AccessIdentification and validation of a novel glycolysis-related gene signature for predicting the prognosis in ovarian cancer
Ovarian cancer (OC) is the most lethal gynaecological tumor. Changes in glycolysis have been proven to play an important role in OC progression. We aimed to identify a novel glycolysis-related gene signature t...
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Article
Open AccessCorrection: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity
A Correction to this paper has been published: https://doi.org/10.1038/s41392-021-00533-3
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Article
Open AccessSmall molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity
Mitochondrial fusion/fission dynamics plays a fundamental role in neuroprotection; however, there is still a severe lack of therapeutic targets for this biological process. Here, we found that the naturally de...
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Article
Open AccessCUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma
CUL4A has been known for its oncogenic properties in various human cancers. However, its role in intrahepatic cholangiocarcinoma (iCCA) has not been explored.
