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Safety and Pharmacokinetics of HTL0018318, a Novel M₁ Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects

HTL0018318 is a selective muscarinic M₁ receptor partial agonist under development for the symptomatic treatment of dementias, including Alzheimer’s disease. Clinically, HTL0018318 would likely be used alone or i...

Charlotte Bakker, Jasper van der Aart, Geert Labots, Jan Liptrot… in Drugs in R&D (2021)