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Article
Open AccessIL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...
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Article
Patient-specific reference model estimation for orthognathic surgical planning
Accurate estimation of reference bony shape models is fundamental for orthognathic surgical planning. Existing methods to derive this model are of two types: one determines the reference model by estimating th...
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Article
The error sample feature compensation method for improving the robustness of underwater classification and recognition models
With the intensification of ocean exploration and development in recent years, the navigation equipment in the marine environment has become increasingly diversified, making the marine environment more complex...
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Article
Towards imbalanced motion: part-decoupling network for video portrait segmentation
Video portrait segmentation (VPS), aiming at segmenting prominent foreground portraits from video frames, has received much attention in recent years. However, the simplicity of existing VPS datasets leads to ...
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Article
Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion
(20 S)-Ginsenoside Rh2 is a natural saponin derived from Panax ginseng Meyer (P. ginseng), which showed significantly potent anticancer properties. However, its low water solubility and bioavailability strongl...
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Article
Open AccessAssessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches
To assess renal interstitial fibrosis (IF) using diffusion MRI approaches, and explore whether corticomedullary difference (CMD) of diffusion parameters, combination among MRI parameters, or combination with e...
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Article
Open AccessRetraction Note: Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines
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Article
Open AccessTunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study
Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...
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Article
Open AccessGravitational lensing by transparent Janis–Newman–Winicour naked singularities
The Janis–Newman–Winicour (JNW) spacetime can describe a naked singularity with a photon sphere that smoothly transforms into a Schwarzschild black hole. Our analysis reveals that photons, upon entering the ph...
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Article
Open AccessEffect of locomotor preference on the evolution of mitochondrial genes in Bovidae
Locomotor preferences and habitat types may drive animal evolution. In this study, we speculated that locomotor preference and habitat type may have diverse influences on Bovidae mitochondrial genes. We used s...
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Article
Open AccessA novel score for predicting falls in community-dwelling older people: a derivation and validation study
Early detection of patients at risk of falling is crucial. This study was designed to develop and internally validate a novel risk score to classify patients at risk of falls.
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Article
Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial
The vascular endothelial growth factor pathway plays a key role in the pathogenesis of gastric cancer. In the multicenter, double-blind phase 3 FRUTIGA trial, 703 patients with advanced gastric or gastroesopha...
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Article
Open AccessDissecting the role of soybean rhizosphere-enriched bacterial taxa in modulating nitrogen-cycling functions
Crop roots selectively recruit certain microbial taxa that are essential for supporting their growth. Within the recruited microbes, some taxa are consistently enriched in the rhizosphere across various locati...
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Article
Solid Desiccant Heat Pump Fresh Air Unit using Composite Silica Gel
The introduction of fresh air into the indoor space leads to a significant increase in cooling or heating loads. Solid desiccant heat pump fresh air unit which can handle the latent and sensible load of fresh ...
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Article
Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial
Treatment with anti-programmed cell death protein 1 (PD-1) therapy and chemotherapy prolongs the survival of patients with unresectable advanced or metastatic gastric or gastroesophageal junction (GEJ) adenoca...
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Article
Joint face normalization and representation learning for face recognition
Identity-independent factors, such as variations of pose, expression, illumination, etc., are the key challenges in face recognition. To avoid the effects of these factors, existing face recognition methods us...
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Article
Open AccessCamrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346...
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Article
Open AccessThe varying clinical effectiveness of single, three and five intraarticular injections of platelet-rich plasma in knee osteoarthritis
To investigate the variations in clinical effectiveness among patients diagnosed with knee osteoarthritis who underwent intra-articular administration of platelet-rich plasma using single, triple, or quintuple...
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Article
Cross-Cultural Generalizability of the First Year Inventory for Early ASD Screening in China
The First Year Inventory (FYI) is a parent report screening measure, aimed at identifying the risk of autism spectrum disorder (ASD) in 12-month-old infants. This study aimed to investigate the utility of FYI ...
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Article
Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up
Although transvaginal mesh (TVM) repair is no longer used in some countries, long-term outcomes after TVM surgery are of great importance globally. However, reports with follow-up >10 years are limited. Thus, ...
