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Article
Open AccessIL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...
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Article
Open AccessAssessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches
To assess renal interstitial fibrosis (IF) using diffusion MRI approaches, and explore whether corticomedullary difference (CMD) of diffusion parameters, combination among MRI parameters, or combination with e...
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Article
Open AccessRetraction Note: Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines
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Article
Open AccessTunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study
Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...
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Article
Open AccessGravitational lensing by transparent Janis–Newman–Winicour naked singularities
The Janis–Newman–Winicour (JNW) spacetime can describe a naked singularity with a photon sphere that smoothly transforms into a Schwarzschild black hole. Our analysis reveals that photons, upon entering the ph...
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Open AccessEffect of locomotor preference on the evolution of mitochondrial genes in Bovidae
Locomotor preferences and habitat types may drive animal evolution. In this study, we speculated that locomotor preference and habitat type may have diverse influences on Bovidae mitochondrial genes. We used s...
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Article
Open AccessA novel score for predicting falls in community-dwelling older people: a derivation and validation study
Early detection of patients at risk of falling is crucial. This study was designed to develop and internally validate a novel risk score to classify patients at risk of falls.
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Article
Open AccessDissecting the role of soybean rhizosphere-enriched bacterial taxa in modulating nitrogen-cycling functions
Crop roots selectively recruit certain microbial taxa that are essential for supporting their growth. Within the recruited microbes, some taxa are consistently enriched in the rhizosphere across various locati...
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Article
Open AccessCamrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346...
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Article
Open AccessThe varying clinical effectiveness of single, three and five intraarticular injections of platelet-rich plasma in knee osteoarthritis
To investigate the variations in clinical effectiveness among patients diagnosed with knee osteoarthritis who underwent intra-articular administration of platelet-rich plasma using single, triple, or quintuple...
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Article
Open AccessGroup IV topological quantum alloy and the role of short-range order: the case of Ge-rich Ge1–xPbx
Despite the explosion of interest in topological materials over the last decades, their applications remain limited due to challenges in growth and incorporation with today’s microelectronics. As a potential b...
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Open AccessThe discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis
Recently, carbon quantum dots (CQDs) have been widely used in various fields, especially in the diagnosis and therapy of neurological disorders, due to their excellent prospects. However, the associated inevit...
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Open AccessRETRACTED ARTICLE: Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines
Hydrazides, N-N containing structural motifs, are important due to their presence in a wide variety of biologically significant compounds. While the homo N-N coupling of two NH moieties to form the hydrazide N...
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Article
Open AccessThe FBXW7-binding sites on FAM83D are potential targets for cancer therapy
Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how FAM83D exerts its oncogenic function remains largely unclear. Here, we investigated the importance of FAM83D/FBXW7 interactio...
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Open AccessRelationship between circadian eating behavior (daily eating frequency and nighttime fasting duration) and cardiovascular mortality
Knowledge regarding the health impacts of daily eating frequency (DEF) and nighttime fasting duration (NFD) on mortality is very limited.
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Article
Open AccessMetabolomic machine learning predictor for diagnosis and prognosis of gastric cancer
Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide, underscoring an urgent need for the development of early detection strategies and precise postoperative interventions....
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Article
Open AccessElastic properties and tensile strength of 2D Ti3C2Tx MXene monolayers
Two-dimensional (2D) transition metal nitrides and carbides (MXenes), represented by Ti3C2Tx, have broad applications in flexible electronics, electromechanical devices, and structural membranes due to their uniq...
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Article
Open AccessSynthesis of 2D layered transition metal (Ni, Co) hydroxides via edge-on condensation
Layered transition metal hydroxides (LTMHs) with transition metal centers sandwiched between layers of coordinating hydroxide anions have attracted considerable interest for their potential in develo** clean...
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Open AccessMaternal smoking, nutritional factors at different life stage, and the risk of incident type 2 diabetes: a prospective study of the UK Biobank
This study aims to investigate potential interactions between maternal smoking around birth (MSAB) and type 2 diabetes (T2D) pathway-specific genetic risks in relation to the development of T2D in offspring. A...
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Article
Open AccessCEO power, corporate risk management, and dividends: disentangling CEO managerial ability from entrenchment
We contribute to the literature on dividend policy by considering two largely ignored, yet important factors, namely CEO power and corporate risk management. We first disentangle CEO managerial ability from en...
