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  1. Article

    Open Access

    Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig

    Establishment and maintenance of pregnancy in the pig involves intricate communication between the develo** conceptuses and the maternal endometrium. This process occurs during trophoblast elongation which i...

    Jason W Ross, Morgan D Ashworth, Daniel Mathew in Reproductive Biology and Endocrinology (2010)

  2. No Access

    Protocol

    Methods for Studying Interferon Tau Stimulated Genes

    Interferon (IFN)τ, a Type I IFN produced by the conceptus trophectoderm, is the pregnancy recognition signal in ruminants that prevents development of the endometrial luteolytic mechanism. In addition, IFNτ ac...

    Fuller W. Bazer, Thomas E. Spencer in Placenta and Trophoblast (2006)

  3. No Access

    Protocol

    Sheep Uterine Gland Knockout (UGKO) Model

    Endometrial gland development is a postnatal event in the ovine uterus that can be inhibited epigenetically by chronic exposure of ewe lambs to a synthetic progestin after birth. The uterus of neonatally proge...

    Thomas E. Spencer, C. Allison Gray in Placenta and Trophoblast (2006)

  4. Article

    Open Access

    Trophoblast biology: Forum introduction

    In mammals, a carefully orchestrated dialogue between the mother and conceptus (embryo/fetus and associate extraembryonic membranes) is initiated during the peri-implantation period of pregnancy as the trophob...

    Thomas E Spencer, Fuller W Bazer in Reproductive Biology and Endocrinology (2004)

  5. Article

    Open Access

    Conceptus signals for establishment and maintenance of pregnancy

    Establishment and maintenance of pregnancy results from signaling by the conceptus (embryo/fetus and associated extraembryonic membranes) and requires progesterone produced by the corpus luteum (CL). In most m...

    Thomas E Spencer, Fuller W Bazer in Reproductive Biology and Endocrinology (2004)

  6. Article

    Open Access

    Effects of the estrous cycle, pregnancy and interferon tau on expression of cyclooxygenase two (COX-2) in ovine endometrium

    In sheep, the uterus produces luteolytic pulses of prostaglandin F (PGF) on Days 15 to 16 of estrous cycle to regress the corpus luteum (CL). These PGF pulses are produced by the endometrial lumenal epithelium ...

    Seokwoon Kim, Youngsok Choi, Thomas E Spencer in Reproductive Biology and Endocrinology (2003)

  7. No Access

    Chapter and Conference Paper

    Cytokines and Pregnancy Recognition

    Maternal recognition of pregnancy results from signaling between the trophoblast of the conceptus (embryo and associated membranes) and the maternal system (1). These signals ensure maintenance of the structur...

    Fuller W. Bazer, Thomas E. Spencer, Troy L. Ott in Immunobiology of Reproduction (1994)