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    Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS

    Measurement of 3-hydroxyisovaleric acid (3HIA) in human urine has been shown to be a useful indicator of biotin status for a variety of clinical situations, including pregnancy. The work described herein prese...

    Thomas D. Horvath, Nell I. Matthews… in Analytical and Bioanalytical Chemistry (2011)