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  1. No Access

    Article

    Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5′-end methylation

    Polymorphisms and decreased activity of methylenetetrahydrofolate reductase (MTHFR) are linked to disease, including cancer. However, epigenetic regulation has not been thoroughly studied. Our goal was to generat...

    Nancy Lévesque, Daniel Leclerc, Tenzin Gayden, Anthoula Lazaris… in Mammalian Genome (2016)

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    Article

    Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

    Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous cell carcinomas. They show that tumors with these p...

    Simon Papillon-Cavanagh, Chao Lu, Tenzin Gayden, Leonie G Mikael… in Nature Genetics (2017)

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    Article

    Spatial heterogeneity in medulloblastoma

    Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using a combination of transcriptomic and genomic profi...

    A Sorana Morrissy, Florence M G Cavalli, Marc Remke, Vijay Ramaswamy… in Nature Genetics (2017)

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    Article

    Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

    Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune activation that adversely affects surv...

    Tenzin Gayden, Fernando E. Sepulveda, Dong-Anh Khuong-Quang… in Nature Genetics (2018)

  5. Article

    Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

    In the version of this article originally published, the main-text sentence “In three patients of European ancestry, we identified the germline variant encoding p.Ile97Met in TIM-3, which was homozygous in two...

    Tenzin Gayden, Fernando E. Sepulveda, Dong-Anh Khuong-Quang… in Nature Genetics (2019)

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