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    Protocol

    Antibody Display Technology (ADbody) to Present Challenging and Unstable Target Proteins on Antibodies

    Antibodies are the major components of adaptive immunity for the recognition of diverse antigens. Six complementarity-determining regions (CDRs) from each heavy chain and light chain present the antigen-bindin...

    Fu-Lien Hsieh, Tao-Hsin Chang in Genotype Phenotype Coupling (2023)

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    Article

    Notum deacylates Wnt proteins to suppress signalling activity

    Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback...

    Satoshi Kakugawa, Paul F. Langton, Matthias Zebisch, Steven A. Howell… in Nature (2015)