89 Result(s)
within
Tao **ong
Biochemistry, general
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Article
Open AccessMultiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization
Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...
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Article
Improvement of thermostability by increasing rigidity in the finger regions and flexibility in the catalytic pocket area of Pseudoalteromonas porphyrae κ-carrageenase
Poor thermostability reduces the industrial application value of κ-carrageenase. In this study, the PoPMuSiC algorithm combined with site-directed mutagenesis was applied to improve the thermostability of the ...
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Article
Open AccessE3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...
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Article
USF2 activates RhoB/ROCK pathway by transcriptional inhibition of miR-206 to promote pyroptosis in septic cardiomyocytes
Septic cardiomyopathy (SCM) is one of the most serious complications of sepsis. The present study investigated the role and mechanism of upstream stimulatory factor 2 (USF2) in SCM. Serum samples were extracte...
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Article
Allelopathy research on the continuous crop** problem of poplar (populus)
The mechanism of decline in continuous plantations is currently a popular research topic in forestry. Continuous crop** is a common obstacle in poplar production and management, and maintaining productivity ...
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Article
Integrating MXene/MWCNTs into aptasensor capable of ultrasensitive quantification of cTnI towards the diagnosis of acute myocardial infarction
The development of a pragmatic biosensor for diagnosing acute myocardial infarction (AMI) is of paramount significance. However, the detection of cardiac Troponin I (cTnI) presents formidable challenges owing ...
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Article
miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
Previous reports have confirmed that miR-206 participates in inflammatory cardiomyopathy, but its definite mechanism remains elusive. This study aims to elucidate the potential mechanism of miR-206 in septic c...
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Article
Open AccessFBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation
Glioblastoma (GBM) is the most common malignant primary brain tumor. Despite comprehensive treatment with traditional surgery, radiotherapy, and chemotherapy, the median survival rate is <14.6% and the 5-year ...
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Article
Correction: miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
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Article
Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages
This study aims to establish a Flow-through Visualization Dissolution System (FVDS) that combines time-lapse macro-imaging and a flow-through cell to simultaneously elucidate dissolution and disintegration pro...
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Article
Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion
The fusion of mononucleated myoblasts produces multinucleated muscle fibers leading to the formation of skeletal muscle. Myomaker, a skeletal muscle-specific membrane protein, is essential for myoblast fusion....
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Article
Open AccessWater-saving techniques: physiological responses and regulatory mechanisms of crops
Water-saving irrigation techniques play a crucial role in addressing water scarcity challenges and promoting sustainable agriculture. However, the selection of appropriate water-saving irrigation methods remai...
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Article
Plasmonic Properties of Gold Central Symmetrical Tetramer in the Visible Regime
In this work, a central symmetrical tetramer structure consisting of gold-broken nanorings is proposed, and the plasmonic properties of the system are investigated in the visible range. Four gold broken nanori...
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Article
Human Serum Albumin-enriched Clopidogrel Bisulfate Nanoparticle Alleviates Cerebral Ischemia–Reperfusion Injury in Rats
Cerebral ischemia–reperfusion (I/R) injury remains a leading cause of mobility and mortality among patients with ischemic stroke. This study aims to develop a human serum albumin (HSA)-enriched nanoparticle platf...
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Article
Total sleep deprivation impairs visual selective attention and triggers a compensatory effect: evidence from event-related potentials
Many studies have demonstrated the impairment of sustained attention due to total sleep deprivation (TSD). However, it remains unclear whether and how TSD affects the processing of visual selective attention. ...
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Article
Hly176B, a low-salt tolerant halolysin from the haloarchaeon Haloarchaeobius sp. FL176
Extracellular proteases of haloarchaea can adapt to high concentrations of NaCl and can find useful applications in industrial or biotechnology processes where hypersaline conditions are desired. The diversity...
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Article
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury
Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special f...
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Article
Plasmonic Characteristics of the Graphene-Photonic Crystal Composite Structure in the IR Regime
In this work, a graphene-photonic crystal composite structure is proposed, in which graphene nanoribbons are placed on top of a photonic crystal that is composed of two alternating dielectric materials. The op...
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Article
Combined analysis of mRNA and miRNA reveals the banana potassium absorption regulatory network and validation of miRNA160a
Potassium (K) has an important effect on the growth and development of plants. Banana contains higher K content than many other fruits, and its plant requires more K nutrient in soil. However, the soil in the ...
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Article
Molecular response and evolution of plant anion transport systems to abiotic stress
We propose that anion channels are essential players for green plants to respond and adapt to the abiotic stresses associated changing climate via reviewing the literature and analyzing the molecular evolution...
