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Article

Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells

Neuroblastoma (NB) is one of the most common childhood malignancies. Currently, high risk NB carries a poor outcome and significant treatment related toxicities and, thus has been a focus for new therapeutics ...

Anjali Singh, Yibing Ruan, Tanya Tippett… in Journal of Experimental & Clinical Cancer … (2015)