12 Result(s)
within
Takeya Kasukawa
Life Sciences
-
Article
Open AccessOVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail old adults
While some old adults stay healthy and non-frail up to late in life, others experience multimorbidity and frailty often accompanied by a pro-inflammatory state. The underlying molecular mechanisms for those di...
-
Article
Open AccessAuthor Correction: IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells
-
Article
Open AccessPrediction of transcription factors associated with DNA demethylation during human cellular development
DNA methylation of CpG dinucleotides is an important epigenetic modification involved in the regulation of mammalian gene expression, with each type of cell develo** a specific methylation profile during its...
-
Article
Open AccessIκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells
Inflammatory stimuli triggers the degradation of three inhibitory κB (IκB) proteins, allowing for nuclear translocation of nuclear factor-κB (NFκB) for transcriptional induction of its target genes. Of these t...
-
Article
Open AccessThe choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background
The lymphatic and the blood vasculature are closely related systems that collaborate to ensure the organism’s physiological function. Despite their common developmental origin, they present distinct functional...
-
Chapter
Single Cell Databases: An Emerging and Essential Tool
As single-cell studies become commonplace, the need for reuse, effective curation, and downstream analysis of data becomes a necessity. The development of single-cell protocols has presented a challenge for da...
-
Article
An integrated expression atlas of miRNAs and their promoters in human and mouse
An atlas of microRNA expression patterns and regulators is produced by deep sequencing of short RNAs in human and mouse cells.
-
Protocol
Genome Annotation
The dynamic structure and functions of genomes are being revealed simultaneously with the progress of technologies and researches in genomics. Evidence indicating genome regional characteristics (genome annota...
-
Protocol
The FANTOM5 Computation Ecosystem: Genomic Information Hub for Promoters and Active Enhancers
The Functional Annotation of the Mammalian Genome 5 (FANTOM5) project conducted transcriptome analysis of various mammalian cell types and provided a comprehensive resource to understand transcriptome and tran...
-
Article
Open AccessGateways to the FANTOM5 promoter level mammalian expression atlas
The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines and tissues using CAGE. Based on manual curation of sample information and deve...
-
Article
Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks
Regulatory loops between transcriptional activators and repressors control the circadian clock. A minimal synthetic combination of these transcription factors is sufficient to drive a robust circadian rhythm.
-
Article
Open AccessAlternate transcription of the Toll-like receptor signaling cascade
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mech...
