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  1. No Access

    Article

    Levonorgestrel-Releasing Intrauterine System Improves Menorrhagia-Related Quality of Life in Patients with Symptomatic Adenomyosis

    Levonorgestrel-releasing intrauterine system (LNG-IUS) relieves dysmenorrhea and heavy menstrual bleeding (HMB) in adenomyosis. However, its efficacy on health-related quality of life (HR-QOL) in patients with...

    Chihiro Ishizawa, Yasushi Hirota, Rei Iida, Tetsuaki Kaku… in Reproductive Sciences (2023)

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    Article

    DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice

    Under ovarian hormone control, dormant blastocysts obtain implantation capacity (known as blastocyst activation) through their global gene expression. After the activated blastocysts communicate with the recep...

    Daiki Hiratsuka, Shizu Aikawa, Yasushi Hirota, Yamato Fukui… in Reproductive Sciences (2023)

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    Article

    Uterine Receptivity is Reflected by LIF Expression in the Cervix

    Recurrent implantation failure is a major problem in assisted reproductive technology (ART). Although ART systems have evolved rapidly over the decades, it is still difficult to diagnose uterine conditions sui...

    Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Chihiro Ishizawa… in Reproductive Sciences (2022)

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    Article

    IL-33 Exacerbates Endometriotic Lesions via Polarizing Peritoneal Macrophages to M2 Subtype

    In endometriosis, M2 macrophages (MΦ) are dominant and promote the development of endometriosis lesions. However, the factor(s) which induces M2 MΦ are unknown. In the present study, we focused on interleukin ...

    Yosuke Ono, Osamu Yoshino, Takehiro Hiraoka, Ikumi Akiyama… in Reproductive Sciences (2020)