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  1. Article

    Open Access

    Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies

    The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Using a 30 G needle, the entire uterine wall of ...

    Mohammed Elsherbini, Kaori Koga, Takehiro Hiraoka, Keiichi Kumasawa in Scientific Reports (2022)

  2. Article

    Open Access

    CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

    In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemoki...

    Yosuke Ono, Osamu Yoshino, Takehiro Hiraoka, Erina Sato, Akiko Furue in Scientific Reports (2021)

  3. Article

    Open Access

    Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment

    Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of uterine epithelial and stromal STAT3 on embryo imp...

    Takehiro Hiraoka, Yasushi Hirota, Yamato Fukui, Mona Gebril in Scientific Reports (2020)

  4. Article

    Open Access

    Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch

    The uterus plays an important and unique role during pregnancy and is a dynamic organ subjected to mechanical stimuli. It has been reported that infertility occurs when the peristalsis is prevented, although i...

    Jeonghyun Kim, Takashi Ushida, Kevin Montagne, Yasushi Hirota in Scientific Reports (2020)