13 Result(s)
within
Takashi Kohno
Cancer Research
Oncology
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Article
Open AccessMechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However, there remain cases where target genes are not identi...
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Open AccessAge at lung cancer diagnosis in females versus males who never smoke by race and ethnicity
We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
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Correction: Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer
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Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer
Delta-like ligand 3 (DLL3) is a therapeutic target in small-cell lung cancer (SCLC). However, how DLL3 expression status affects the tumor microenvironment (TME) and clinical outcomes in SCLC remains unclear.
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Article
A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer
This study aimed to elucidate the clinicopathological and molecular features of HER2-amplified and HER2-low colorectal cancers (CRCs). We also characterised HER2 expression statuses in CRCs focusing on their intr...
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Open AccessUtility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer
We investigated the utility of a molecular classifier tool and genetic alterations for predicting prognosis in Japanese patients with endometrial cancer.
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Open AccessClinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practic...
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Precision medicine for ovarian clear cell carcinoma based on gene alterations
Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this diseas...
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High-grade glioneuronal tumor with an ARHGEF2–NTRK1 fusion gene
Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected ...
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Identification of a novel KLC1–ROS1 fusion in a case of pediatric low-grade localized glioma
The proto-oncogene tyrosine-protein kinase ROS1 (ROS1) is a tyrosine kinase that is closely related to anaplastic lymphoma kinase receptor (ALK). We describe a novel KLC1–ROS1 fusion identified in a case of pedia...
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Open AccessThe first case of SMARCB1 (INI1) - deficient squamous cell carcinoma of the pleura: a case report
SMARCB1 (INI1) is a tumor-suppressor gene located at 22q11.2. Loss of SMARCB1 protein expression has been reported to be associated with atypical teratoid/rhabdoid tumors and malignant rhabdoid tumors of the kidn...
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Open AccessComprehensive screening of target molecules by next-generation sequencing in patients with malignant solid tumors: guiding entry into phase I clinical trials
It is still controversial whether comprehensive genome screening of target molecules by next generation sequencing (NGS) is needed to increase clinical efficacy of investigational drugs or accelerate drug deve...
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Genetic alterations responsible for metastatic phenotypes of lung cancer cells
It is now widely accepted that human carcinogenesis is a multi-step process and phenotypic changes during cancer progression reflect the sequential accumulation of genetic alterations in cells. Thus, in order ...
