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13 Result(s)

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  1. Article

    Open Access

    Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)

    To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practic...

    Yoichi Naito, Hiroyuki Aburatani… in International Journal of Clinical Oncology (2021)

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  2. No Access

    Article

    Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults

    Homologous recombination deficiency (HRD), which influences the efficacy of PARP inhibitor- and platinum agent-based therapies, is a prevalent phenotype of breast cancer in adolescents and young adults (AYAs; ...

    Tomoko Watanabe, Takayuki Honda, Hirohiko Totsuka… in Breast Cancer Research and Treatment (2020)

  3. No Access

    Article

    Precision medicine for ovarian clear cell carcinoma based on gene alterations

    Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this diseas...

    Takafumi Kuroda, Takashi Kohno in International Journal of Clinical Oncology (2020)

  4. No Access

    Article

    High-grade glioneuronal tumor with an ARHGEF2–NTRK1 fusion gene

    Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected ...

    Kazuhiko Kurozumi, Yoshiko Nakano, Joji Ishida, Takehiro Tanaka… in Brain Tumor Pathology (2019)

  5. No Access

    Article

    Identification of a novel KLC1–ROS1 fusion in a case of pediatric low-grade localized glioma

    The proto-oncogene tyrosine-protein kinase ROS1 (ROS1) is a tyrosine kinase that is closely related to anaplastic lymphoma kinase receptor (ALK). We describe a novel KLC1–ROS1 fusion identified in a case of pedia...

    Yoshiko Nakano, Arata Tomiyama, Takashi Kohno, Akihiko Yoshida… in Brain Tumor Pathology (2019)

  6. No Access

    Article

    Probing the chromosome 9p21 region susceptible to DNA double-strand breaks in human cells in vivo by restriction enzyme transfer

    A restriction enzyme, MspI, was introduced into cultured human cells as a probe to detect genomic regions susceptible to DNA double-strand breaks (DSBs). A 2 h exposure to MspI at a concentration of 8 U/μl produc...

    Masanori Sato, Hiroki Sasaki, Teruhisa Kazui, Jun Yokota, Takashi Kohno in Oncogene (2005)

  7. No Access

    Article

    Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo

    To identify genes whose expression is upregulated in lung adenocarcinoma (AdC) cells in comparison with noncancerous peripheral lung epithelial cells, type II alveolar cells and bronchiolar epithelial cells, a...

    Keiko Kobayashi, Michiho Nishioka, Takashi Kohno, Masaki Nakamoto… in Oncogene (2004)

  8. No Access

    Article

    Molecular processes of chromosome 9p21 deletions in human cancers

    Interstitial deletions of the chromosome 9p21 segment encoding the p16/CDKN2A tumor suppressor gene (i.e., 9p21 deletions) are frequently observed in a variety of human cancers. A majority of these deletions in l...

    Shigeru Sasaki, Yukiko Kitagawa, Yoshitaka Sekido, John D Minna… in Oncogene (2003)

  9. No Access

    Article

    Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line

    Frequent allelic losses on chromosome 22q in small cell lung carcinomas (SCLCs) and advanced non-small cell lung carcinomas indicate the presence of tumor suppressor gene(s) on this chromosome arm. We detected...

    Michiho Nishioka, Takashi Kohno, Mina Takahashi, Toshiro Niki, Tesshi Yamada… in Oncogene (2000)

  10. No Access

    Article

    Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers

    Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions...

    Satoshi Takakura, Takashi Kohno, Kimihiro Shimizu, Susumu Ohwada, Aikou Okamoto… in Oncogene (2000)

  11. No Access

    Article

    Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma

    The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. There...

    Yoshio Tomizawa, Takashi Kohno, Takeshi Fujita, Masaharu Kiyama, Ryusei Saito… in Oncogene (1999)

  12. No Access

    Article

    Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

    The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh8Gua) from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were performed in normal and lung cancer cells. Due to a...

    Takashi Kohno, Kazuya Shinmura, Masahiko Tosaka, Masachika Tani, Su-Ryang Kim… in Oncogene (1998)

  13. No Access

    Article

    Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage

    We report the cloning of a human homolog of the yeast OGG1 gene, which encodes a DNA glycosylase that excises an oxidatively damaged form of guanine, 8-hydroxyguanine (also known as 7,8-dihydro-8-oxoguanine). Sin...

    Kiyomitsu Arai, Kazuhiro Morishita, Kazuya Shinmura, Takashi Kohno… in Oncogene (1997)