6 Result(s)
within
Takashi Kohno
Life Sciences
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Article
Open AccessInhibition of the mitochondria-sha** protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome it. Here we show that the mitochondria-sha** protein Opa1 p...
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Article
Long-term expansion of alveolar stem cells derived from human iPS cells in organoids
This paper reports the efficient generation of human alveolar cells from induced pluripotent stem cells and their expansion in 3D culture.
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Article
Open AccessSingle-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment
To understand the heterogeneous behaviors of individual cancer cells, it is essential to investigate gene expression levels as well as their divergence between different individual cells. Recent advances in ne...
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Article
Phenotypic alterations of small cell lung carcinoma induced by different levels of wild-type p53 expression
p53 induces both growth arrest and apoptosis in cancer cells. To clarify whether the level of p53 expression determines the response of small cell lung carcinoma (SCLC) cells, we assessed the effect of various...
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Protocol
PCR Fingerprinting for Detection of Deleted or Amplified Sequences in Human Cancer
Genomic fingerprinting is one of several methods for screening human genome to identify genetic alterations in cancer cells. Arbitrarily primed polymerase chain reaction (AP-PCR) is a PCR-based genomic fingerp...
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Article
Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage
8-Hydroxyguanine (7,8-dihydro-8-oxoguanine: oh8Gua) is a damaged form of guanine induced by oxygen-free radicals and causes GC to TA transversions. Previously we isolated the hOGG1 gene, a human homolog of the ye...
