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Article
Open AccessMedial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study
We reported that the full-length width of medial tibial osteophytes comprising cartilage and bone parts correlates with medial meniscus extrusion (MME) in early-stage knee osteoarthritis (OA). However, no data...
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Article
Open AccessVariant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis
Hereditary stomatocytosis (HSt) is a type of congenital hemolytic anemia caused by abnormally increased cation permeability of erythrocyte membranes. Dehydrated HSt (DHSt) is the most common subtype of HSt and...
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Article
Open AccessClinical and genetic diagnosis of thirteen Japanese patients with hereditary spherocytosis
Hereditary spherocytosis is the most frequent cause of hereditary hemolytic anemia and is classified into five subtypes (SPH1-5) according to OMIM. Because the clinical and laboratory features of patients with...
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Article
Open AccessNovel COL4A1 mutations identified in infants with congenital hemolytic anemia in association with brain malformations
Genetic causes of undiagnosed hemolytic anemia in nineteen patients were analyzed by whole-exome sequencing, and novel COL4A1 variants were identified in four patients (21%). All patients were complicated with co...
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Article
Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis
Osteoarthritis of the knee (knee OA) induces pain, loss of mobility and diminished activities of daily living (ADL). Although an understanding of the pathophysiology of early stage knee OA has been developed, ...
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Article
Open AccessAssociation of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 map** MRI in patients with early-stage knee osteoarthritis
Medial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information is available for relationships between MME and osteophytes, which are found in ca...
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Article
Non-invasive speed of sound measurement in cartilage by use of combined magnetic resonance imaging and ultrasound: an initial study
The speed of sound (SOS) is available as an index of elasticity. Using a combination of magnetic resonance imaging (MRI) and ultrasound, one can measure the SOS. In this study, we verified the accuracy of SOS ...
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Ag+-Induced Inward Current on Frog Skeletal Muscle
Ag+ caused an inward current on voltage-clamped skeletal muscle. The current was carried by Ca2+, Mg2+, and Na+, and was blocked by Cd2+or Ni2+ but not by nifedipine or D600. Channel gating is supposed to be modi...
