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Article
Open AccessMalignant transformation of white sponge nevus: a case report of a novel keratin 4 mutation
White Sponge Nevus (WSN) is traditionally considered a benign genetic disorder affecting the oral mucosa, primarily caused by pathogenic mutations in keratin 4 (KRT4) or keratin 13 (KRT13). Despite its benign nat...
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Article
Open AccessShaoxia: a web-based interactive analysis platform for single cell RNA sequencing data
In recent years, Single-cell RNA sequencing (scRNA-seq) is increasingly accessible to researchers of many fields. However, interpreting its data demands proficiency in multiple programming languages and bioinf...
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Article
Open AccessIdentification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis
Oral submucous fibrosis (OSF) is a chronic and insidious oral potentially malignant disorder associated with a 4–17% risk of oral squamous cell carcinoma (OSCC). Our previous study found that proteasomal activ...
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Article
Open AccessHigh expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-...
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Protocol
Computational Deconvolution of Tumor-Infiltrating Immune Components with Bulk Tumor Gene Expression Data
Tumor-infiltrating immune cells play critical roles in immune-mediated tumor rejection and/or progression, and are key targets of immunotherapies. Estimation of different immune subsets becomes increasingly im...
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Article
Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Landscape of B cell immunity and related immune evasion in human cancers
Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hy...
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Article
Open AccessVIPER: Visualization Pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis
RNA sequencing has become a ubiquitous technology used throughout life sciences as an effective method of measuring RNA abundance quantitatively in tissues and cells. The increase in use of RNA-seq technology ...
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Article
Synthesis of Yb3+, Ho3+ and Tm3+ co-doped β-NaYF4 nanoparticles by sol–gel method and the multi-color upconversion luminescence properties
Well-crystalline β-NaYF4:Yb3+, Ho3+, Tm3+ nanoparticles were synthesized by sol–gel method using isopropyl alcohol [(CH3)2CHOH] as a complexing agent. The samples were characterized by X-ray diffraction, scanning...
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Article
Ultrasensitive detection of TCR hypervariable-region sequences in solid-tissue RNA–seq data
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Article
Open AccessComprehensive analyses of tumor immunity: implications for cancer immunotherapy
Understanding the interactions between tumor and the host immune system is critical to finding prognostic biomarkers, reducing drug resistance, and develo** new therapies. Novel computational methods are nee...
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Article
Landscape of tumor-infiltrating T cell repertoire of human cancers
Shirley Liu, Jun Liu and colleagues present a computational method to infer the CDR3 sequences of tumor-infiltrating T cells from RNA-seq data. They apply the method to 9,142 samples across 29 cancer types and...
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Chapter and Conference Paper
Mechanism Design of the Inspection Robot for Aircraft Fuel Tank
To improve reliability and security of the aircraft fuel tank inspection and decrease labor intensity of maintenance personnel, an inspection robot is developed. Maintenance workers’ work, which include enteri...
