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  1. Article

    Open Access

    Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

    Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically asses...

    E. A. M. Calvier, E. H. J. Krekels, T. N. Johnson, A. Rostami-Hodjegan… in The AAPS Journal (2019)

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