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  1. Article

    Gene therapy progress and prospects cancer: oncolytic viruses

    The past 2 years have seen several major advances in oncolytic virotherapy. Studies on the interaction between viruses, immune responses and tumor microenvironment have provided important insight, while clinic...

    T-C Liu, D Kirn in Gene Therapy (2008)

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    Treatment of Implantable NF2 Schwannoma Tumor Models with Oncolytic Herpes Simplex Virus G47Δ

    Schwannomas are benign tumors composed of dedifferentiated Schwann cells that form along peripheral nerves causing nerve compression often associated with pain and loss of function. Current surgical therapy in...

    S Prabhakar, S M Messerli, A O Stemmer-Rachamimov, T-C Liu, S Rabkin… in Cancer Gene Therapy (2007)

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    Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus

    Replication-selective oncolytic adenoviruses hold promise, but novel mechanisms must be identified to maximize intratumoral virus persistence, spread and therapeutic transgene-carrying capacity while maintaini...

    T-C Liu, Y Wang, G Hallden, G Brooks, J Francis, N R Lemoine, D Kirn in Gene Therapy (2005)