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  1. No Access

    Article

    Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-κB and ATF4

    Under anoxia a coordinated, cytoprotective program is induced, called the unfolded protein response (UPR). Activating transcription factor 4 (ATF4) is a mediator of the UPR and activates a gene expression prog...

    T Rzymski, A Paantjens, J Bod, A L Harris in Oncogene (2008)

  2. No Access

    Article

    An oncogenic role of eIF3e/INT6 in human breast cancer

    Altered expression of the eukaryotic translation initiation factor 3 (eIF3) subunit eIF3e/INT6 has been described in various types of human cancer, but the nature of its involvement in tumorigenesis is not yet...

    M Grzmil, T Rzymski, M Milani, A L Harris, R G Capper, N J Saunders, A Salhan… in Oncogene (2010)

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    Article

    Regulation of autophagy by ATF4 in response to severe hypoxia

    Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cell...

    T Rzymski, M Milani, L Pike, F Buffa, H R Mellor, L Winchester, I Pires… in Oncogene (2010)

  4. No Access

    Article

    The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

    The family of ADAM (a disintegrin and metalloproteinase) proteins has been implicated in tumor initiation and progression. ADAM17/tumor necrosis factor-α (TNFα)-converting enzyme (TACE) has been initially reco...

    T Rzymski, A Petry, D Kračun, F Rieß, L Pike, A L Harris, A Görlach in Oncogene (2012)