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Article
Toll-like receptors mediate proliferation and survival of multiple myeloma cells
Multiple myeloma (MM) is an incurable B-cell malignancy characterized by accumulation of malignant plasma cells in bone marrow (BM) and recurrent or persistent infections. Toll-like receptors (TLRs) are essent...
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Article
CD68+/CD83+/CD1a− dendritic cell subsets from patients with multiple myeloma are not infected with human herpesvirus 8
Recently, a subset of dendritic cells with the phenotype CD68+/CD83+/CD1a−, present in patients with multiple myeloma (MM), was reported to be infected with human herpesvirus 8 (HHV-8). Therefore we wished to cla...
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Article
Selective loss of progenitor subsets following clinical CD34+ cell enrichment by magnetic field, magnetic beads or chromatography separation
In this preclinical evaluation we have compared the efficacy of three clinical CD34+enrichment procedures with respect to purity, yield and recovery, as well as risk of selective loss of CD34+ lineage-specific su...
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Article
Reduced bone marrow stem cell pool and progenitor mobilisation in multiple myeloma after melphalan treatment
The content of stem cells was analysed in bone marrow samples from 75 multiple myeloma patients. In unstimulated bone marrow the percentage of CD34+cells was significantly reduced in 11 patients previously tre...