4 Result(s)
within
T Dörk
Epidemiology
Oncology
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Article
Open AccessFGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF...
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Article
Open AccessEvaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor recep...
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Article
Open AccessATM polymorphisms as risk factors for prostate cancer development
The risk of prostate cancer is known to be elevated in carriers of germline mutations in BRCA2, and possibly also in carriers of BRCA1 and CHEK2 mutations. These genes are components of the ATM-dependent DNA dama...
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Article
Open AccessMutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer
Mutations of the BRCA1 or BRCA2 genes have been shown to strongly predispose towards the development of contralateral breast cancer in patients from large multi-case families. In order to test the hypothesis that...
