3 Result(s)
within
T Bruno
Cell Biology
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Article
Che-1 activates XIAP expression in response to DNA damage
X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family that selectively binds and inhibits caspase-3, -7 and -9. As such, XIAP is an extremely potent suppresso...
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Article
Open AccessHIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation
Che-1/AATF is an RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in response to DNA damage. We have previously demonst...
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Article
Open AccessChe-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53
The tumor suppressor p53 is mainly involved in the transcriptional regulation of a large number of growth-arrest- and apoptosis-related genes. However, a clear understanding of which factor/s influences the ch...
